Osteoporosis in swine

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Lorenzett, Marina P.
Cecco, Bianca S.
Bianchi, Matheus V.
Cruz, Raquel A.S.
Guedes, Roberto M.C.
Driemeier, David
Pavarini, Saulo P.
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Colégio Brasileiro de Patologia Animal - CBPA
Linhares, Daniel
Associate Professor
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Veterinary Diagnostic and Production Animal Medicine
The mission of VDPAM is to educate current and future food animal veterinarians, population medicine scientists and stakeholders by increasing our understanding of issues that impact the health, productivity and well-being of food and fiber producing animals; developing innovative solutions for animal health and food safety; and providing the highest quality, most comprehensive clinical practice and diagnostic services. Our department is made up of highly trained specialists who span a wide range of veterinary disciplines and species interests. We have faculty of all ranks with expertise in diagnostics, medicine, surgery, pathology, microbiology, epidemiology, public health, and production medicine. Most have earned certification from specialty boards. Dozens of additional scientists and laboratory technicians support the research and service components of our department.
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Veterinary Diagnostic and Production Animal Medicine
Forty-six pigs presented muscle weakness, hind limb paresis and paralysis, weight loss, lateral recumbency, and death in a clinical course of 7 to 10 days. Two pigs were necropsied and exhibited bone fragility, bone callus formation, and multiple fractures in the limbs, ribs, and vertebrae. Microscopically, there was a diffuse and marked decrease in thickness and number of trabeculae. These were disconnected, with a “free-floating” appearance, while the cortex of the long bones was thinned, with an increase of the cortical porosity by enlargement of Haversian canals and endosteal erosion and decreased osteoblastic activity. Flame atomic absorption spectrometry in liver samples revealed significant zinc overload (>2300ppm) and copper deficiency (<33.1ppm). In this communication, we present the first pathologic description of an outbreak of osteoporosis in pigs, and we also provide a brief review of metabolic bone diseases in pigs.
This article is published as Lorenzett M.P., Cecco B.S., Bianchi M.V., Cruz R.A.S., Linhares D.C.L., Guedes R.M.C., Driemeier D. & Pavarini S.P. 2022. Osteoporosis in swine. Pesquisa Veterinária Brasileira 42:e07068, 2022. DOI: 10.1590/1678-5150-PVB-7068. Attribution 4.0 International (CC BY NC 4.0). Posted with permission.