Excited-State Intramolecular Hydrogen Atom Transfer and Solvation Dynamics of the Medicinal Pigment Curcumin

dc.contributor.author Adhikary, Ramkrishna
dc.contributor.author Mukherjee, Prasun
dc.contributor.author Petrich, Jacob
dc.contributor.author Kee, Tak
dc.contributor.author Petrich, Jacob
dc.contributor.department Chemistry
dc.date 2018-02-17T08:37:17.000
dc.date.accessioned 2020-06-30T01:21:09Z
dc.date.available 2020-06-30T01:21:09Z
dc.date.copyright Thu Jan 01 00:00:00 UTC 2009
dc.date.issued 2009-03-24
dc.description.abstract <p>The potential use of the naturally occurring yellow-orange pigment curcumin as a photodynamic therapy agent is one of the most exciting applications of this medicinal compound. Although subnanosecond spectroscopy has been used to investigate the photophysical processes of curcumin, the time resolution is insufficient to detect important and faster photoinduced processes, including solvation and excited-state intramolecular hydrogen atom transfer (ESIHT). In this study, the excited-state photophysics of curcumin is studied by means of ultrafast fluorescence upconversion spectroscopy. The results show two decay components in the excited-state kinetics with time scales of 12−20 ps and ∼100 ps in methanol and ethylene glycol. The resulting prominent isotope effect in the long component upon deuteration indicates that curcumin undergoes ESIHT in these solvents. The short component (12−20 ps) is insensitive to deuteration, and multiwavelength fluorescence upconversion results show that this decay component is due to solvation of excited-state curcumin.</p>
dc.description.comments <p>Reprinted (adapted) with permission from <em>Journal of Physical Chemistry B</em> 113 (2009): 5255, doi: <a href="http://dx.doi.org/10.1021/jp901234z" target="_blank">10.1021/jp901234z</a>. Copyright 2009 American Chemical Society.</p>
dc.format.mimetype application/pdf
dc.identifier archive/lib.dr.iastate.edu/chem_pubs/565/
dc.identifier.articleid 1535
dc.identifier.contextkey 7942798
dc.identifier.s3bucket isulib-bepress-aws-west
dc.identifier.submissionpath chem_pubs/565
dc.identifier.uri https://dr.lib.iastate.edu/handle/20.500.12876/15036
dc.language.iso en
dc.source.bitstream archive/lib.dr.iastate.edu/chem_pubs/565/0-2009_PetrichJW_ExcitedStateIntramolecular.pdf|||Sat Jan 15 00:57:49 UTC 2022
dc.source.bitstream archive/lib.dr.iastate.edu/chem_pubs/565/2009_PetrichJW_ExcitedStateIntramolecular.pdf|||Sat Jan 15 00:57:50 UTC 2022
dc.source.uri 10.1021/jp901234z
dc.subject.disciplines Chemistry
dc.subject.disciplines Physical Chemistry
dc.subject.keywords Atomic spectroscopy
dc.subject.keywords deuterium
dc.subject.keywords ethylene
dc.subject.keywords ethylene glycol
dc.subject.keywords fluorescence
dc.subject.keywords free radical reactions
dc.subject.keywords hydrogen
dc.subject.keywords methanol
dc.subject.keywords photodynamic therapy
dc.subject.keywords solvation
dc.subject.keywords curcumin
dc.subject.keywords decay components
dc.subject.keywords deuteration
dc.subject.keywords excited-state
dc.subject.keywords fluorescence upconversion
dc.subject.keywords intramolecular hydrogens
dc.subject.keywords isotope effects
dc.subject.keywords photophysics
dc.title Excited-State Intramolecular Hydrogen Atom Transfer and Solvation Dynamics of the Medicinal Pigment Curcumin
dc.type article
dc.type.genre article
dspace.entity.type Publication
relation.isAuthorOfPublication 563e8d72-b6e9-4617-91c0-589d263e00fc
relation.isOrgUnitOfPublication 42864f6e-7a3d-4be3-8b5a-0ae3c3830a11
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