Vaccination against Lawsonia intracellularis decreases shedding of Salmonella enterica serovar typhimurium in co-infected pigs and changes the host gut microbiome

Abstract

<p>Salmonella enterica is a leading cause of foodborne illness in the world. Attribution studies have suggested pork as a major source for human salmonellosis in different countries (Mughini-Gras et al., 2013, Pires et al., 2014). In the United States, efforts to reduce the incidence of salmonellosis have mainly remained ineffective, the incidence of salmonellosis has not been reduced appreciably since 1996 (Boore et al., 2015). There is a consensus in the field that there is a lack of on farm cost-effective strategies to reduce the prevalence of salmonellosis (Dickson & Hurd, 2013). The source of S. enterica that contaminates pork products are the animals themselves (Dickson & Hurd, 2013) and novel intervention strategies are much needed.</p>