Estrogenic Activity of Glycitein, a Soy Isoflavone Song, Tong Hendrich, Suzanne Hendrich, Suzanne Murphy, Patricia
dc.contributor.department Food Science and Human Nutrition 2018-02-15T11:06:30.000 2020-06-30T03:59:55Z 2020-06-30T03:59:55Z Fri Jan 01 00:00:00 UTC 1999 2014-01-31 1999-03-24
dc.description.abstract <p>Glycitein (4‘,7-dihydroxy-6-methoxyisoflavone) accounts for 5−10% of the total isoflavones in soy food products. The biological activity of this compound has not been reported to date, although numerous studies have been performed with the other soy isoflavones, daidzein and genistein. Glycitein was isolated from soy germ to 99% purity. Weaning female B6D2F1 mice were dosed with glycitein (3 mg/day), genistein (3 mg/day), and diethylstilbestrol (DES) (0.03 μg/day) in 5% Tween 80 by gavage for 4 days. A control group received an equal volume of 5% Tween 80 solution daily. The uterine weight increased 150% with glycitein (<em>p</em> < 0.001), 50% with genistein (<em>p</em> < 0.001), and 60% with DES (<em>p</em> < 0.001) compared with the control group. DES, 17β-estradiol, and three isoflavones (daidzein, genistein, and glycitein) were examined for their competitive binding abilities with 17β-(3H)estradiol to the estrogen receptor proteins of the B6D2F1 mouse uterine cytosol. The concentrations of each compound required to displace 50% of the (3H)estradiol at 5 nM in the competitive binding assay were 1.15 nM DES, 1.09 nM 17β-estradiol, 0.22 μM genistein, 4.00 μM daidzein, and 3.94 μM glycitein. These data indicated that glycitein has weak estrogenic activity, comparable to that of the other soy isoflavones but much lower than that of DES and 17β-estradiol.</p>
dc.description.comments <p>Reprinted with permission from <em>Journal of Agricultural and Food Chemistry</em>, 47(4):1607-1610. doi: <a href="" target="_blank">10.1021/jf981054j</a>. Copyright 1999 American Chemical Society.</p>
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dc.identifier archive/
dc.identifier.articleid 1096
dc.identifier.contextkey 6360609
dc.identifier.s3bucket isulib-bepress-aws-west
dc.identifier.submissionpath fshn_ag_pubs/90
dc.language.iso en
dc.source.bitstream archive/|||Sat Jan 15 02:26:39 UTC 2022
dc.source.bitstream archive/|||Sat Jan 15 02:26:41 UTC 2022
dc.source.uri 10.1021/jf981054j
dc.subject.disciplines Food Science
dc.subject.disciplines Human and Clinical Nutrition
dc.subject.disciplines Other Animal Sciences
dc.subject.keywords Isoflavone
dc.subject.keywords glycitein
dc.subject.keywords genistein
dc.subject.keywords daidzein
dc.subject.keywords phytoestrogen
dc.subject.keywords estrogenic activity
dc.title Estrogenic Activity of Glycitein, a Soy Isoflavone
dc.type article
dc.type.genre article
dspace.entity.type Publication
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relation.isOrgUnitOfPublication 4b6428c6-1fda-4a40-b375-456d49d2fb80
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