Identification of signatures of selection for intramuscular fat and backfat thickness in two Duroc populations

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dc.contributor.author Kim, Eui-Soo
dc.contributor.author Ros-Freixedes, Roger
dc.contributor.author Rothschild, Max
dc.contributor.author Pena, Ramona
dc.contributor.author Baas, Thomas
dc.contributor.author Estany, Joan
dc.contributor.author Rothschild, Max
dc.contributor.department Animal Science
dc.date 2018-02-17T11:42:08.000
dc.date.accessioned 2020-06-29T23:39:13Z
dc.date.available 2020-06-29T23:39:13Z
dc.date.copyright Thu Jan 01 00:00:00 UTC 2015
dc.date.issued 2015-01-01
dc.description.abstract <p>Intramuscular fat (IMF) content is an important trait affecting the quality of pork. Two Duroc populations, one under positive selection for IMF and the other selected for decreased backfat but under stabilizing selection for IMF, were used to identify signatures of selection associated with IMF using 60,000 single-nucleotide polymorphism data. The effects of selection were analyzed between 2 lines or groups representing selected and control animals within each population using a discriminant analysis of principal components and Wright’s fixation index (F<sub>ST</sub>). Moreover, extended haplotype homozygosity-based approaches were used to examine the changes in haplotype frequency due to recent selection. Each statistical method identified 10–20 selection signatures. A few haplotype-based signatures of selection agreed with results from a genome-wide association study (GWAS), while F<sub>ST</sub> measures showed a better agreement with GWAS results. Agreement of marker-trait associations and signatures of selection was limited, and further examination will be necessary to understand the effect of selection on IMF and why some regions identified by GWAS did not appear to respond to the selection practiced. The genes in 21 consensus selection signatures were examined. Several genes with an effect on overall fatness were identified, but further research is needed to assess whether or not some of them could have a specific effect on IMF.</p>
dc.description.comments <p>This is an article from <em>Journal of Animal Science</em> 93 (2015): 3292, doi:<a href="http://dx.doi.org/10.2527/jas.2015-8879" target="_blank">10.2527/jas.2015-8879</a>. Posted with permission.</p>
dc.format.mimetype application/pdf
dc.identifier archive/lib.dr.iastate.edu/ans_pubs/235/
dc.identifier.articleid 1220
dc.identifier.contextkey 8071526
dc.identifier.s3bucket isulib-bepress-aws-west
dc.identifier.submissionpath ans_pubs/235
dc.identifier.uri https://dr.lib.iastate.edu/handle/20.500.12876/9642
dc.language.iso en
dc.source.bitstream archive/lib.dr.iastate.edu/ans_pubs/235/2015_Rothschild_IdentificationSignatures.pdf|||Fri Jan 14 22:48:47 UTC 2022
dc.source.uri 10.2527/jas.2015-8879
dc.subject.disciplines Agriculture
dc.subject.disciplines Animal Sciences
dc.subject.keywords Duroc
dc.subject.keywords genes
dc.subject.keywords genome-wide associations
dc.subject.keywords intramuscular fat
dc.subject.keywords selection signatures
dc.title Identification of signatures of selection for intramuscular fat and backfat thickness in two Duroc populations
dc.type article
dc.type.genre article
dspace.entity.type Publication
relation.isAuthorOfPublication a5915699-0c8a-411e-a601-1564d7090ab9
relation.isOrgUnitOfPublication 85ecce08-311a-441b-9c4d-ee2a3569506f
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