Mapping and Investigation of Novel Candidate Genes for Fatness, Growth, and Feed Intake in the Pig

dc.contributor.author Kim, K.
dc.contributor.author Malek, M.
dc.contributor.author Rothschild, Max
dc.contributor.author Grindflek, E.
dc.contributor.author Marklund, S.
dc.contributor.author Rothschild, Max
dc.date 2018-02-13T00:09:17.000
dc.date.accessioned 2020-07-02T07:00:44Z
dc.date.available 2020-07-02T07:00:44Z
dc.date.copyright Sat Jan 01 00:00:00 UTC 2000
dc.date.embargo 2012-08-17
dc.date.issued 2000-01-01
dc.description.abstract <p>Five new candidate genes for fatness, growth, and feed intake traits were studied. The genes were chosen based on their presumed biological action for a given trait of interest. A molecular genetics polymerase chain reaction-restriction fragment length polymorphisms (PCR-RFLP) approach was used to identify genetic differences (polymorphisms) in the porcine melanocortin-4 receptor (MC4R), melanocortin-5 receptor (MC5R), cocaine and amphetamine-regulated transcript (CART), peroxisome proliferator activated receptor _ (PPAR_), and prepro-orexin genes. These genes were genetically mapped using several markers on porcine chromosomes (SSC) 1, 6, 12, 13, and 16, respectively. All five genes also were physically mapped with a pig/rodent somatic cell hybrid panel. The physical locations of all five genes are as follows: MC4R (SSC1q22-27), MC5R (SSC6q24-(1/2)q31), prepro-orexin (SSC12p13- p11), PPAR_ (SSC13q23-q41), and CART (SSC16q21). The localization of these genes is reasonably consistent with previous chromosome painting results, indicating conserved (similar) regions between human and pig chromosomes. We also looked at the effect of these genes on traits of interest. The effect of a MC4R polymorphism was investigated in a large population of pigs from several commercial lines. MC4R genotypes were significantly associated with fatness, growth rate, and feed intake traits. Further studies on the effect of these candidate genes are underway.</p>
dc.format.mimetype application/pdf
dc.identifier archive/lib.dr.iastate.edu/swinereports_1999/1/
dc.identifier.articleid 1014
dc.identifier.contextkey 3227904
dc.identifier.s3bucket isulib-bepress-aws-west
dc.identifier.submissionpath swinereports_1999/1
dc.identifier.uri https://dr.lib.iastate.edu/handle/20.500.12876/91174
dc.language.iso en
dc.relation.ispartofseries Animal Science Research Reports
dc.relation.ispartofseries ASL R1672
dc.source.bitstream archive/lib.dr.iastate.edu/swinereports_1999/1/asl_1672.pdf|||Fri Jan 14 17:27:52 UTC 2022
dc.subject.disciplines Agriculture
dc.subject.disciplines Animal Sciences
dc.subject.keywords ASL R1672
dc.title Mapping and Investigation of Novel Candidate Genes for Fatness, Growth, and Feed Intake in the Pig
dc.type article
dc.type.genre breeding_physiology
dspace.entity.type Publication
relation.isAuthorOfPublication a5915699-0c8a-411e-a601-1564d7090ab9
relation.isSeriesOfPublication 7f3839b7-b833-4418-a6fa-adda2b23950a
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