Improvement of Lipid Absorption in Young Pigs as a Model for Preterm Infants

dc.contributor.author Carnagey, K.
dc.contributor.author Lewis, D.
dc.contributor.author Stewart, J.
dc.contributor.author Beitz, Donald
dc.date 2018-08-25T22:42:46.000
dc.date.accessioned 2020-06-29T23:28:16Z
dc.date.available 2020-06-29T23:28:16Z
dc.date.copyright Thu Jan 01 00:00:00 UTC 2004
dc.date.issued 2004-01-01
dc.description.abstract <p>Preterm infants and neonatal suckling piglets have a limited bile acid pool that may hinder absorption of dietary lipids such as fatty acids, triacylglycerols (TAGs), and other lipid-soluble nutrients. Because dietary lipids are a valuable source of energy for growth, it is important that they are efficiently absorbed. The hypothesis of this study is that oral administration of 0.2 g/kg body weight daily of cholylsarcosine, an artificial bile acid, would decrease fecal excretion of dietary fatty acids and TAGs in suckling piglets. Twelve 7-d-old piglets were housed individually and fed a commercial milk replacer with or without oral cholylsarcosine until 21 d of age. Cholylsarcosine treatment decreased fecal excretion of stearic acid (18:0) and palmitic acid (16:0) (P ≤ 0.02). Cholylsarcosine supplementation had no effect on absorption of unsaturated fatty acids of 16 or 18 carbons (P > 0.05). Cholylsarcosine increased fecal excretion of deoxycholic acid (P = 0.03). Apparent absorption of dietary TAGs was increased from 77% in piglets not fed cholylsarcosine to 83% in the piglets that received oral cholylsarcosine. These results support the hypothesis that cholylsarcosine increases absorption of dietary TAGs.</p>
dc.identifier archive/lib.dr.iastate.edu/ans_air/vol650/iss1/117/
dc.identifier.articleid 1117
dc.identifier.contextkey 3311008
dc.identifier.doi https://doi.org/10.31274/ans_air-180814-833
dc.identifier.s3bucket isulib-bepress-aws-west
dc.identifier.submissionpath ans_air/vol650/iss1/117
dc.identifier.uri https://dr.lib.iastate.edu/handle/20.500.12876/8086
dc.language.iso en
dc.relation.ispartofseries Animal Science Research Reports
dc.source.bitstream archive/lib.dr.iastate.edu/ans_air/vol650/iss1/117/AS1958.pdf|||Fri Jan 14 18:55:54 UTC 2022
dc.subject.disciplines Agriculture
dc.subject.disciplines Animal Sciences
dc.subject.keywords ASL R1958
dc.title Improvement of Lipid Absorption in Young Pigs as a Model for Preterm Infants
dc.type article
dc.type.genre swine
dspace.entity.type Publication
relation.isJournalIssueOfPublication 3f2790ae-9c11-4703-87e0-39b318362bbc
relation.isSeriesOfPublication 7f3839b7-b833-4418-a6fa-adda2b23950a
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