A dual-target molecular mechanism of pyrethrum repellency against mosquitoes
dc.contributor.author | Liu, Feng | |
dc.contributor.author | Wang, Qiang | |
dc.contributor.author | Coats, Joel | |
dc.contributor.author | Xu, Peng | |
dc.contributor.author | Andreazza, Felipe | |
dc.contributor.author | Valbon, Wilson | |
dc.contributor.author | Bandason, Elizabeth | |
dc.contributor.author | Chen, Mengli | |
dc.contributor.author | Yan, Ru | |
dc.contributor.author | Feng, Bo | |
dc.contributor.author | Smith, Leticia | |
dc.contributor.author | Scott, Jeffrey | |
dc.contributor.author | Takamatsu, Genki | |
dc.contributor.author | Ihara, Makoto | |
dc.contributor.author | Matsuda, Kazuhiko | |
dc.contributor.author | Klimavicz, James | |
dc.contributor.author | Coats, Joel | |
dc.contributor.author | Oliveira, Eugenio | |
dc.contributor.author | Du, Yuzhe | |
dc.contributor.author | Dong, Ke | |
dc.contributor.department | Entomology | |
dc.date | 2021-05-12T21:11:51.000 | |
dc.date.accessioned | 2021-08-14T04:59:36Z | |
dc.date.available | 2021-08-14T04:59:36Z | |
dc.date.copyright | Fri Jan 01 00:00:00 UTC 2021 | |
dc.date.issued | 2021-01-01 | |
dc.description.abstract | <p>Pyrethrum extracts from flower heads of <em>Chrysanthemum</em> spp. have been used worldwide in insecticides and repellents. While the molecular mechanisms of its insecticidal action are known, the molecular basis of pyrethrum repellency remains a mystery. In this study, we find that the principal components of pyrethrum, pyrethrins, and a minor component, (E)-β-farnesene (EBF), each activate a specific type of olfactory receptor neurons in <em>Aedes aegypti</em> mosquitoes. We identify <em>Ae. aegypti</em> odorant receptor 31 (AaOr31) as a cognate Or for EBF and find that Or31-mediated repellency is significantly synergized by pyrethrin-induced activation of voltage-gated sodium channels. Thus, pyrethrum exerts spatial repellency through a novel, dual-target mechanism. Elucidation of this two-target mechanism may have potential implications in the design and development of a new generation of synthetic repellents against major mosquito vectors of infectious diseases.</p> | |
dc.description.comments | <p>This article is published as Liu, F., Wang, Q., Xu, P. <em>et al.</em> A dual-target molecular mechanism of pyrethrum repellency against mosquitoes. <em>Nat Commun</em> 12, 2553 (2021). doi:<a href="https://doi.org/10.1038/s41467-021-22847-0">10.1038/s41467-021-22847-0</a>.</p> | |
dc.format.mimetype | application/pdf | |
dc.identifier | archive/lib.dr.iastate.edu/ent_pubs/593/ | |
dc.identifier.articleid | 1594 | |
dc.identifier.contextkey | 22898648 | |
dc.identifier.s3bucket | isulib-bepress-aws-west | |
dc.identifier.submissionpath | ent_pubs/593 | |
dc.identifier.uri | https://dr.lib.iastate.edu/handle/20.500.12876/Nr1V57Bz | |
dc.language.iso | en | |
dc.source.bitstream | archive/lib.dr.iastate.edu/ent_pubs/593/2021_Coats_DualTarget.pdf|||Sat Jan 15 01:04:03 UTC 2022 | |
dc.source.uri | 10.1038/s41467-021-22847-0 | |
dc.subject.disciplines | Entomology | |
dc.subject.disciplines | Infectious Disease | |
dc.subject.disciplines | Molecular Genetics | |
dc.title | A dual-target molecular mechanism of pyrethrum repellency against mosquitoes | |
dc.type | article | |
dc.type.genre | article | |
dspace.entity.type | Publication | |
relation.isAuthorOfPublication | 8bcdfc38-7da7-4e3c-8039-e495b01cc710 | |
relation.isOrgUnitOfPublication | f47c8cad-50be-4fb0-8870-902ff536748c |
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