A dual-target molecular mechanism of pyrethrum repellency against mosquitoes

dc.contributor.author Liu, Feng
dc.contributor.author Wang, Qiang
dc.contributor.author Coats, Joel
dc.contributor.author Xu, Peng
dc.contributor.author Andreazza, Felipe
dc.contributor.author Valbon, Wilson
dc.contributor.author Bandason, Elizabeth
dc.contributor.author Chen, Mengli
dc.contributor.author Yan, Ru
dc.contributor.author Feng, Bo
dc.contributor.author Smith, Leticia
dc.contributor.author Scott, Jeffrey
dc.contributor.author Takamatsu, Genki
dc.contributor.author Ihara, Makoto
dc.contributor.author Matsuda, Kazuhiko
dc.contributor.author Klimavicz, James
dc.contributor.author Coats, Joel
dc.contributor.author Oliveira, Eugenio
dc.contributor.author Du, Yuzhe
dc.contributor.author Dong, Ke
dc.contributor.department Entomology
dc.date 2021-05-12T21:11:51.000
dc.date.accessioned 2021-08-14T04:59:36Z
dc.date.available 2021-08-14T04:59:36Z
dc.date.copyright Fri Jan 01 00:00:00 UTC 2021
dc.date.issued 2021-01-01
dc.description.abstract <p>Pyrethrum extracts from flower heads of <em>Chrysanthemum</em> spp. have been used worldwide in insecticides and repellents. While the molecular mechanisms of its insecticidal action are known, the molecular basis of pyrethrum repellency remains a mystery. In this study, we find that the principal components of pyrethrum, pyrethrins, and a minor component, (E)-β-farnesene (EBF), each activate a specific type of olfactory receptor neurons in <em>Aedes aegypti</em> mosquitoes. We identify <em>Ae. aegypti</em> odorant receptor 31 (AaOr31) as a cognate Or for EBF and find that Or31-mediated repellency is significantly synergized by pyrethrin-induced activation of voltage-gated sodium channels. Thus, pyrethrum exerts spatial repellency through a novel, dual-target mechanism. Elucidation of this two-target mechanism may have potential implications in the design and development of a new generation of synthetic repellents against major mosquito vectors of infectious diseases.</p>
dc.description.comments <p>This article is published as Liu, F., Wang, Q., Xu, P. <em>et al.</em> A dual-target molecular mechanism of pyrethrum repellency against mosquitoes. <em>Nat Commun</em> 12, 2553 (2021). doi:<a href="https://doi.org/10.1038/s41467-021-22847-0">10.1038/s41467-021-22847-0</a>.</p>
dc.format.mimetype application/pdf
dc.identifier archive/lib.dr.iastate.edu/ent_pubs/593/
dc.identifier.articleid 1594
dc.identifier.contextkey 22898648
dc.identifier.s3bucket isulib-bepress-aws-west
dc.identifier.submissionpath ent_pubs/593
dc.identifier.uri https://dr.lib.iastate.edu/handle/20.500.12876/Nr1V57Bz
dc.language.iso en
dc.source.bitstream archive/lib.dr.iastate.edu/ent_pubs/593/2021_Coats_DualTarget.pdf|||Sat Jan 15 01:04:03 UTC 2022
dc.source.uri 10.1038/s41467-021-22847-0
dc.subject.disciplines Entomology
dc.subject.disciplines Infectious Disease
dc.subject.disciplines Molecular Genetics
dc.title A dual-target molecular mechanism of pyrethrum repellency against mosquitoes
dc.type article
dc.type.genre article
dspace.entity.type Publication
relation.isAuthorOfPublication 8bcdfc38-7da7-4e3c-8039-e495b01cc710
relation.isOrgUnitOfPublication f47c8cad-50be-4fb0-8870-902ff536748c
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