A whole genome scan for quantitative trait loci for leg weakness and its related traits in a large F2 intercross population between White Duroc and Erhualian

dc.contributor.author Guo, Y. M.
dc.contributor.author Ai, H. S.
dc.contributor.author Rothschild, Max
dc.contributor.author Ren, J.
dc.contributor.author Wang, G. J.
dc.contributor.author Wen, Y.
dc.contributor.author Mao, H. R.
dc.contributor.author Lan, L. T.
dc.contributor.author Ma, J. W.
dc.contributor.author Brenig, B.
dc.contributor.author Rothschild, Max
dc.contributor.author Haley, C. S.
dc.contributor.author Huang, L. S.
dc.contributor.department Animal Science
dc.date 2018-02-17T11:53:41.000
dc.date.accessioned 2020-06-29T23:39:19Z
dc.date.available 2020-06-29T23:39:19Z
dc.date.copyright Thu Jan 01 00:00:00 UTC 2009
dc.date.issued 2009-01-01
dc.description.abstract <p>To detect QTL for leg weakness and its related traits in pigs, a total of 1,484 F<sub>2</sub> pigs were recorded for leg (at 76 and 213 d) and gait scores (at 153 and 223 d) in a White Duroc × Erhualian intercross. The length and weight of the biceps brachii muscle were measured after slaughter at 240 d. A genome scan was performed with 183 microsatellite markers in the population. A total of 42 QTL were detected, including 16 at the 1% genome-wide significant level and 6 at the 5% genome-wide significant level. Thirty-eight of the 42 QTL showed significant additive effects, and 14 had significant dominance effects. At least 2 QTL were detected for each trait except for leg score at 76 d, for which no QTL was identified. Some of the QTL for leg and gait scores confirmed previous findings. Eighteen QTL were detected for weight and length of the biceps brachii muscle. To our knowledge, this was the first report about QTL for weight and length of the biceps brachii muscle in pigs. Two chromosome regions each on SSC4 and SSC7 showed significant and multiple associations with both leg weakness and growth of the biceps brachii muscle, which are worthwhile for further investigation.</p>
dc.description.comments <p>This is an article from <em>Journal of Animal Science</em> 87 (2009): 1569, doi:<a href="http://dx.doi.org/10.2527/jas.2008-1191" target="_blank">10.2527/jas.2008-1191</a>. Posted with permission.</p>
dc.format.mimetype application/pdf
dc.identifier archive/lib.dr.iastate.edu/ans_pubs/247/
dc.identifier.articleid 1244
dc.identifier.contextkey 8082528
dc.identifier.s3bucket isulib-bepress-aws-west
dc.identifier.submissionpath ans_pubs/247
dc.identifier.uri https://dr.lib.iastate.edu/handle/20.500.12876/9655
dc.language.iso en
dc.source.bitstream archive/lib.dr.iastate.edu/ans_pubs/247/2009_Rothschild_WholeGenome.pdf|||Fri Jan 14 22:54:30 UTC 2022
dc.source.uri 10.2527/jas.2008-1191
dc.subject.disciplines Agriculture
dc.subject.disciplines Animal Sciences
dc.subject.disciplines Genetics and Genomics
dc.subject.disciplines Veterinary Medicine
dc.subject.keywords biceps brachii muscle
dc.subject.keywords gait score
dc.subject.keywords leg score
dc.subject.keywords pig
dc.subject.keywords quantitative trait loci
dc.title A whole genome scan for quantitative trait loci for leg weakness and its related traits in a large F2 intercross population between White Duroc and Erhualian
dc.type article
dc.type.genre article
dspace.entity.type Publication
relation.isAuthorOfPublication a5915699-0c8a-411e-a601-1564d7090ab9
relation.isOrgUnitOfPublication 85ecce08-311a-441b-9c4d-ee2a3569506f
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