Increasingly, the varied usage of antibiotics in food producing animals has come under greater regulatory and retail scrutiny. Consumer attitudes towards the use of antibiotics in the food supply chain continue to drive this increased scrutiny. The delivery of immune stimulating antigens through vaccination is well documented as a mechanism for the prevention and control of disease causing agents. Through proper application, vaccination can play a vital role in the reduction of antibiotic use without compromising animal welfare. In that context the challenge is to provide economic returns to primary producers through reduced production costs and/or increased returns following a vaccine implementation.