Native State Proline Isomerization:  An Intrinsic Molecular Switch Andreotti, Amy Andreotti, Amy
dc.contributor.department Biochemistry, Biophysics and Molecular Biology 2018-02-17T03:47:54.000 2020-06-29T23:45:55Z 2020-06-29T23:45:55Z Wed Jan 01 00:00:00 UTC 2003 2003-07-01
dc.description.abstract <p>Exquisite control of biological function is achieved via tight regulation of the catalytic and binding activities of cellular proteins. The mechanistic details of protein regulation vary from targeted chemical modification of amino acid side chains (1) to the quite drastic global unfolding of an entire polypeptide chain (2). Peptidyl prolyl cis/trans isomerization is emerging as a potentially general mechanism for the control of protein function (3). While most structures of native, folded proteins reveal peptidyl-prolyl imide bonds that adopt either the cis or trans conformation, there are a growing number of folded proteins that exhibit conformational heterogeneity about one or more peptidyl-prolyl bonds. Unlike covalent modification or global unfolding, proline isomerization is an intrinsic conformational exchange process that has the potential to direct ligand recognition and to control protein activity within the confines of the native state.</p>
dc.description.comments <p>Reprinted (adapted) with permission from <em>Biochemistry </em>42 (2003), 9515, doi:<a href="" target="_blank">10.1021/bi0350710</a>. Copyright 2003 American Chemical Society.</p>
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dc.identifier archive/
dc.identifier.articleid 1031
dc.identifier.contextkey 7747980
dc.identifier.s3bucket isulib-bepress-aws-west
dc.identifier.submissionpath bbmb_ag_pubs/14
dc.language.iso en
dc.source.bitstream archive/|||Fri Jan 14 20:08:47 UTC 2022
dc.source.bitstream archive/|||Fri Jan 14 20:08:48 UTC 2022
dc.source.uri 10.1021/bi0350710
dc.subject.disciplines Biochemistry, Biophysics, and Structural Biology
dc.subject.disciplines Molecular Biology
dc.title Native State Proline Isomerization:  An Intrinsic Molecular Switch
dc.type article
dc.type.genre article
dspace.entity.type Publication
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