Native State Proline Isomerization:  An Intrinsic Molecular Switch

dc.contributor.author Andreotti, Amy
dc.contributor.author Andreotti, Amy
dc.contributor.department Biochemistry, Biophysics and Molecular Biology
dc.date 2018-02-17T03:47:54.000
dc.date.accessioned 2020-06-29T23:45:55Z
dc.date.available 2020-06-29T23:45:55Z
dc.date.copyright Wed Jan 01 00:00:00 UTC 2003
dc.date.issued 2003-07-01
dc.description.abstract <p>Exquisite control of biological function is achieved via tight regulation of the catalytic and binding activities of cellular proteins. The mechanistic details of protein regulation vary from targeted chemical modification of amino acid side chains (1) to the quite drastic global unfolding of an entire polypeptide chain (2). Peptidyl prolyl cis/trans isomerization is emerging as a potentially general mechanism for the control of protein function (3). While most structures of native, folded proteins reveal peptidyl-prolyl imide bonds that adopt either the cis or trans conformation, there are a growing number of folded proteins that exhibit conformational heterogeneity about one or more peptidyl-prolyl bonds. Unlike covalent modification or global unfolding, proline isomerization is an intrinsic conformational exchange process that has the potential to direct ligand recognition and to control protein activity within the confines of the native state.</p>
dc.description.comments <p>Reprinted (adapted) with permission from <em>Biochemistry </em>42 (2003), 9515, doi:<a href="http://dx.doi.org/10.1021/bi0350710" target="_blank">10.1021/bi0350710</a>. Copyright 2003 American Chemical Society.</p>
dc.format.mimetype application/pdf
dc.identifier archive/lib.dr.iastate.edu/bbmb_ag_pubs/14/
dc.identifier.articleid 1031
dc.identifier.contextkey 7747980
dc.identifier.s3bucket isulib-bepress-aws-west
dc.identifier.submissionpath bbmb_ag_pubs/14
dc.identifier.uri https://dr.lib.iastate.edu/handle/20.500.12876/10599
dc.language.iso en
dc.source.bitstream archive/lib.dr.iastate.edu/bbmb_ag_pubs/14/0-AndreottiLicense_NativeState.pdf|||Fri Jan 14 20:08:47 UTC 2022
dc.source.bitstream archive/lib.dr.iastate.edu/bbmb_ag_pubs/14/2003_Andreotti_NativeStateProline.pdf|||Fri Jan 14 20:08:48 UTC 2022
dc.source.uri 10.1021/bi0350710
dc.subject.disciplines Biochemistry, Biophysics, and Structural Biology
dc.subject.disciplines Molecular Biology
dc.title Native State Proline Isomerization:  An Intrinsic Molecular Switch
dc.type article
dc.type.genre article
dspace.entity.type Publication
relation.isAuthorOfPublication 97143b55-8496-4365-8699-e254a8ac0903
relation.isOrgUnitOfPublication c70f85ae-e0cd-4dce-96b5-4388aac08b3f
File
Original bundle
Now showing 1 - 2 of 2
Name:
2003_Andreotti_NativeStateProline.pdf
Size:
683.37 KB
Format:
Adobe Portable Document Format
Description:
Name:
0-AndreottiLicense_NativeState.pdf
Size:
252.55 KB
Format:
Adobe Portable Document Format
Description:
Collections