Experimental Study Using Multiple Strains of Prion Disease in Cattle Reveals an Inverse Relationship between Incubation Time and Misfolded Prion Accumulation, Neuroinflammation, and Autophagy
dc.contributor.author | Mammadova, Najiba | |
dc.contributor.author | Greenlee, M. Heather | |
dc.contributor.author | Moore, S. Jo | |
dc.contributor.author | Sakaguchi, Donald | |
dc.contributor.author | Greenlee, Justin | |
dc.contributor.department | Biomedical Sciences | |
dc.contributor.department | Immunobiology | |
dc.contributor.department | Neuroscience | |
dc.contributor.department | Genetics, Development and Cell Biology | |
dc.date | 2020-04-13T19:13:14.000 | |
dc.date.accessioned | 2020-06-30T04:02:13Z | |
dc.date.available | 2020-06-30T04:02:13Z | |
dc.date.issued | 2020-07-01 | |
dc.description.abstract | Proteinopathies result from aberrant folding and accumulation of specific proteins. Currently, there is a lack of knowledge about the factors that influence disease progression, making this a key challenge for the development of therapies for proteinopathies. Because of the similarities between transmissible spongiform encephalopathies (TSEs) and other protein misfolding diseases, TSEs can be used to understand other proteinopathies. Bovine spongiform encephalopathy (BSE) is a TSE that occurs in cattle and can be subdivided into three strains: classic BSE and atypical BSEs (H and L types) that have shorter incubation periods. The NACHT, LRR, and PYD domains–containing protein 3 inflammasome is a critical component of the innate immune system that leads to release of IL-1β. Macroautophagy is an intracellular mechanism that plays an essential role in protein clearance. In this study, the retina was used as a model to investigate the relationship between disease incubation period, prion protein accumulation, neuroinflammation, and changes in macroautophagy. We demonstrate that atypical BSEs present with increased prion protein accumulation, neuroinflammation, and decreased autophagy. This work suggests a relationship between disease time course, neuroinflammation, and the autophagic stress response, and may help identify novel therapeutic biomarkers that can delay or prevent the progression of proteinopathies. | |
dc.description.comments | <p>This article is published as Mammadova, Najiba, M. Heather West Greenlee, S. Jo Moore, Donald S. Sakaguchi, and Justin J. Greenlee. "Experimental study using multiple strains of prion disease in cattle reveals an inverse relationship between incubation time and misfolded prion accumulation, neuroinflammation and autophagy." <em>The American Journal of Pathology</em> 190 (2020):1461-1473. doi: <a href="https://doi.org/10.1016/j.ajpath.2020.03.006" target="_blank" title="Persistent link using digital object identifier">10.1016/j.ajpath.2020.03.006</a>. Works produced by employees of the U.S. Government as part of their official duties are not copyrighted within the U.S. The content of this document is not copyrighted.</p> | |
dc.format.mimetype | application/pdf | |
dc.identifier | archive/lib.dr.iastate.edu/gdcb_las_pubs/244/ | |
dc.identifier.articleid | 1248 | |
dc.identifier.contextkey | 17348917 | |
dc.identifier.s3bucket | isulib-bepress-aws-west | |
dc.identifier.submissionpath | gdcb_las_pubs/244 | |
dc.identifier.uri | https://dr.lib.iastate.edu/handle/20.500.12876/37921 | |
dc.language.iso | en | |
dc.source.bitstream | archive/lib.dr.iastate.edu/gdcb_las_pubs/244/2020_Sakaguchi_ExperimentalStudyManuscript.pdf|||Fri Jan 14 22:53:44 UTC 2022 | |
dc.source.uri | 10.1016/j.ajpath.2020.03.006 | |
dc.subject.disciplines | Cell and Developmental Biology | |
dc.subject.disciplines | Veterinary Microbiology and Immunobiology | |
dc.subject.disciplines | Veterinary Pathology and Pathobiology | |
dc.subject.keywords | autophagy | |
dc.subject.keywords | bovine spongiform encephalopathy | |
dc.subject.keywords | incubation period | |
dc.subject.keywords | NLRP3 inflammasome | |
dc.subject.keywords | prion disease | |
dc.subject.keywords | retina | |
dc.title | Experimental Study Using Multiple Strains of Prion Disease in Cattle Reveals an Inverse Relationship between Incubation Time and Misfolded Prion Accumulation, Neuroinflammation, and Autophagy | |
dc.type | article | |
dc.type.genre | article | |
dspace.entity.type | Publication | |
relation.isAuthorOfPublication | 917b7591-023b-4249-b9eb-ba479084bead | |
relation.isOrgUnitOfPublication | 184db3f2-d93f-4571-8ad7-07c8a9e6a5c9 | |
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relation.isOrgUnitOfPublication | 69754788-3b0f-45f3-be4d-004c4d08715e | |
relation.isOrgUnitOfPublication | 9e603b30-6443-4b8e-aff5-57de4a7e4cb2 |
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