Drosophila Kruppel homolog 1 represses lipolysis through interaction with dFOXO

dc.contributor.author Kang, Ping
dc.contributor.author Chang, Kai
dc.contributor.author Liu, Ying
dc.contributor.author Bouska, Mark
dc.contributor.author Birnbaum, Allison
dc.contributor.author Karashchuk, Galina
dc.contributor.author Thakore, Rachel
dc.contributor.author Zheng, Wenjing
dc.contributor.author Post, Stephanie
dc.contributor.author Brent, Colin S.
dc.contributor.author Li, Sheng
dc.contributor.author Tatar, Marc
dc.contributor.author Bai, Hua
dc.contributor.department Genetics, Development and Cell Biology
dc.date.accessioned 2022-03-25T14:38:48Z
dc.date.available 2022-03-25T14:38:48Z
dc.date.issued 2017-11-27
dc.description.abstract Transcriptional coordination is a vital process contributing to metabolic homeostasis. As one of the key nodes in the metabolic network, the forkhead transcription factor FOXO has been shown to interact with diverse transcription co-factors and integrate signals from multiple pathways to control metabolism, oxidative stress response, and cell cycle. Recently, insulin/FOXO signaling has been implicated in the regulation of insect development via the interaction with insect hormones, such as ecdysone and juvenile hormone. In this study, we identified an interaction between Drosophila FOXO (dFOXO) and the zinc finger transcription factor Kruppel homolog 1 (Kr-h1), one of the key players in juvenile hormone signaling. We found that Kr-h1 mutants show delayed larval development and altered lipid metabolism, in particular induced lipolysis upon starvation. Notably, Kr-h1 physically and genetically interacts with dFOXO in vitro and in vivo to regulate the transcriptional activation of insulin receptor (InR) and adipose lipase brummer (bmm). The transcriptional co-regulation by Kr-h1 and dFOXO may represent a broad mechanism by which Kruppel-like factors integrate with insulin signaling to maintain metabolic homeostasis and coordinate organism growth.
dc.description.comments This article is published as Kang, P., Chang, K., Liu, Y. et al. Drosophila Kruppel homolog 1 represses lipolysis through interaction with dFOXO. Sci Rep 7, 16369 (2017). https://doi.org/10.1038/s41598-017-16638-1. Works produced by employees of the U.S. Government as part of their official duties are not copyrighted within the U.S. The content of this document is not copyrighted.
dc.identifier.uri https://dr.lib.iastate.edu/handle/20.500.12876/1wgePX9r
dc.language.iso en
dc.source.uri https://doi.org/10.1038/s41598-017-16638-1 *
dc.title Drosophila Kruppel homolog 1 represses lipolysis through interaction with dFOXO
dc.type Article
dspace.entity.type Publication
relation.isAuthorOfPublication ae16dcee-afdf-4805-9590-eb7a0bb1d0f1
relation.isOrgUnitOfPublication 7bab215d-4571-4c33-867c-28881af20485
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