Serum and mammary secretion antibody responses in porcine epidemic diarrhea-immune gilts following porcine epidemic diarrhea vaccination

Date
2018-01
Authors
Bjustrom-Kraft, Jordan
Woodard, Katie
Giménez-Lirola, Luis
Setness, Blake
Ji, Ju
Lasley, Pete
Nelson, Eric
Zhang, Jianqiang
Baum, David
Gauger, Phillip
Main, Rodger
Zimmerman, Jeff
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American Association of Swine Veterinarians
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Giménez-Lirola, Luis
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Veterinary Diagnostic and Production Animal MedicineStatistics
Abstract
Materials and methods: PEDV antibody-positive gilts (n = 36) in a commercial production system were each randomly (www.random.org) assigned to one of five vaccination protocols: no vaccine (controls); PEDV vaccine A (2 weeks pre-farrow); PEDV vaccine A (5 and 2 weeks pre-farrow); PEDV vaccine B (2 weeks pre-farrow); and PEDV vaccine B (5 and 2 weeks pre-farrow). Serum, colostrum, and milk samples collected over the course of the study were tested for PEDV IgG, IgA, and neutralizing antibody (NAb). Results: Analysis of the data from 32 animals completing the study found that vaccine induced a clear anamnestic response, ie, vaccinates had higher antibody concentrations than controls for most tests and specimens, but no difference was detected between one versus two doses of vaccine, and few differences in response were detected for vaccine A versus B. A positive but weak correlation was detected between IgG in serum and IgA in colostrum (P = .012; r = .44). Implications: Under the conditions of this study, PEDV-vaccinated gilts have higher IgG, IgA, and NAb responses than nonvaccinated controls in all diagnostic specimens tested. In breeding herds, direct measurement of PEDV IgA or NAb in colostrum and milk will provide a more accurate measurement of lactogenic immunity than serological testing.
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This article is published as Bjustrom-Kraft, Jordan, Katie Woodard, Luis Giménez-Lirola, Blake Setness, Ju Ji, Pete Lasley, Eric Nelson et al. "Serum and mammary secretion antibody responses in porcine epidemic diarrhea-immune gilts following porcine epidemic diarrhea vaccination." Journal of Swine Health and Production 26, no. 1 (2018): 34-40. DOI: 10.1186/s12917-016-0725-5. Copyright 2019 American Association of Swine Veterinarians. Posted with permission.
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