Reduction of Pulmonary Mast Cells in Areas of Acute Inflammation in Calves with Mannheimia (Pasteurella) haemolytica Pneumonia

Date
2000-07-01
Authors
Gallup, Jack
Ramírez-Romero, Rafael
Brogden, Kim
Gallup, Jack
Ackermann, Mark
Dixon, Richard
Ackermann, Mark
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Veterinary Pathology
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Veterinary Pathology
Abstract

Mast cells in the left cranial pulmonary lobe of colostrum-deprived neonatal calves were quantified 2 and 6 h after intrabronchial inoculation with Mannheimia (Pasteurella) haemolytica A1. The mast cells were detected (1) immunohistochemically with a mouse anti-human mast cell tryptase monoclonal antibody, and (2) by metachromatic staining with low pH toluidine blue. A greater number of mast cells was demonstrated by the second method than by the first. At 6 h after inoculation, but not at 2 h, the number of mast cells was significantly reduced at the site of the main lesions. Treatment of calves with a sialyl Lewis mimetic (TBC1269) did not appreciably affect the results at 6 h.

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This article is from Journal of Comparative Pathology 123, no 1 (July 2000): 29–35, doi:10.1053/jcpa.1999.0383.

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