Synthetic lectins for selective binding of glycoproteins in water
dc.contributor.author | Duan, Likun | |
dc.contributor.author | Zangiabadi, Milad | |
dc.contributor.author | Zhao, Yan | |
dc.contributor.department | Department of Chemistry | |
dc.date | 2021-04-21T20:44:19.000 | |
dc.date.accessioned | 2021-04-30T00:16:00Z | |
dc.date.available | 2021-04-30T00:16:00Z | |
dc.date.copyright | Wed Jan 01 00:00:00 UTC 2020 | |
dc.date.issued | 2020-01-01 | |
dc.description.abstract | <p>Although synthetic mimics of lectins can be extremely useful in biological and biomedical research, molecular recognition of carbohydrates has been hampered by their strong solvation in water and subtle structural differences among analogues. Molecularly imprinted nanoparticle receptors were prepared with glycans directly cleaved from glycoproteins. Functionalized with boroxole groups in the binding sites, these water-soluble synthetic lectins bound the parent glycoproteins selectively in water with an association constant of Ka = 104–105 M−1. The strong binding enabled the receptors to protect the targeted glycans from enzymatic cleavage. When clicked onto magnetic nanoparticles, the receptors enabled facile isolation of glycoproteins from a mixture.</p> | |
dc.description.comments | <p>This article is published as Duan, Likun, Milad Zangiabadi, and Yan Zhao. "Synthetic lectins for selective binding of glycoproteins in water." <em>Chemical Communications</em> 56, no. 70 (2020): 10199-10202. DOI: <a href="https://doi.org/10.1039/D0CC02892D" target="_blank">10.1039/D0CC02892D</a>. Posted with permission.</p> | |
dc.format.mimetype | application/pdf | |
dc.identifier | archive/lib.dr.iastate.edu/chem_pubs/1304/ | |
dc.identifier.articleid | 2306 | |
dc.identifier.contextkey | 22579492 | |
dc.identifier.s3bucket | isulib-bepress-aws-west | |
dc.identifier.submissionpath | chem_pubs/1304 | |
dc.identifier.uri | https://dr.lib.iastate.edu/handle/20.500.12876/104673 | |
dc.language.iso | en | |
dc.source.bitstream | archive/lib.dr.iastate.edu/chem_pubs/1304/2021_ZhaoYan_SyntheticLectins.pdf|||Fri Jan 14 19:42:56 UTC 2022 | |
dc.source.uri | 10.1039/D0CC02892D | |
dc.subject.disciplines | Organic Chemistry | |
dc.title | Synthetic lectins for selective binding of glycoproteins in water | |
dc.type | article | |
dc.type.genre | article | |
dspace.entity.type | Publication | |
relation.isAuthorOfPublication | 82f430d1-77c0-43c2-8bd5-52f3787cc4ba | |
relation.isOrgUnitOfPublication | 42864f6e-7a3d-4be3-8b5a-0ae3c3830a11 |
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