Synthetic lectins for selective binding of glycoproteins in water

dc.contributor.author Duan, Likun
dc.contributor.author Zangiabadi, Milad
dc.contributor.author Zhao, Yan
dc.contributor.department Department of Chemistry
dc.date 2021-04-21T20:44:19.000
dc.date.accessioned 2021-04-30T00:16:00Z
dc.date.available 2021-04-30T00:16:00Z
dc.date.copyright Wed Jan 01 00:00:00 UTC 2020
dc.date.issued 2020-01-01
dc.description.abstract <p>Although synthetic mimics of lectins can be extremely useful in biological and biomedical research, molecular recognition of carbohydrates has been hampered by their strong solvation in water and subtle structural differences among analogues. Molecularly imprinted nanoparticle receptors were prepared with glycans directly cleaved from glycoproteins. Functionalized with boroxole groups in the binding sites, these water-soluble synthetic lectins bound the parent glycoproteins selectively in water with an association constant of Ka = 104–105 M−1. The strong binding enabled the receptors to protect the targeted glycans from enzymatic cleavage. When clicked onto magnetic nanoparticles, the receptors enabled facile isolation of glycoproteins from a mixture.</p>
dc.description.comments <p>This article is published as Duan, Likun, Milad Zangiabadi, and Yan Zhao. "Synthetic lectins for selective binding of glycoproteins in water." <em>Chemical Communications</em> 56, no. 70 (2020): 10199-10202. DOI: <a href="https://doi.org/10.1039/D0CC02892D" target="_blank">10.1039/D0CC02892D</a>. Posted with permission.</p>
dc.format.mimetype application/pdf
dc.identifier archive/lib.dr.iastate.edu/chem_pubs/1304/
dc.identifier.articleid 2306
dc.identifier.contextkey 22579492
dc.identifier.s3bucket isulib-bepress-aws-west
dc.identifier.submissionpath chem_pubs/1304
dc.identifier.uri https://dr.lib.iastate.edu/handle/20.500.12876/104673
dc.language.iso en
dc.source.bitstream archive/lib.dr.iastate.edu/chem_pubs/1304/2021_ZhaoYan_SyntheticLectins.pdf|||Fri Jan 14 19:42:56 UTC 2022
dc.source.uri 10.1039/D0CC02892D
dc.subject.disciplines Organic Chemistry
dc.title Synthetic lectins for selective binding of glycoproteins in water
dc.type article
dc.type.genre article
dspace.entity.type Publication
relation.isAuthorOfPublication 82f430d1-77c0-43c2-8bd5-52f3787cc4ba
relation.isOrgUnitOfPublication 42864f6e-7a3d-4be3-8b5a-0ae3c3830a11
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