Synergistic Effects of Anti-CmeA and Anti-CmeB Peptide Nucleic Acids on Sensitizing Campylobacter jejuni to Antibiotics
dc.contributor.author | Mu, Yang | |
dc.contributor.author | Shen, Zhangqi | |
dc.contributor.author | Jeon, Byeonghwa | |
dc.contributor.author | Dai, Lei | |
dc.contributor.author | Zhang, Qijing | |
dc.contributor.department | Veterinary Microbiology and Preventive Medicine | |
dc.date | 2018-02-18T23:25:42.000 | |
dc.date.accessioned | 2020-07-07T05:14:39Z | |
dc.date.available | 2020-07-07T05:14:39Z | |
dc.date.copyright | Tue Jan 01 00:00:00 UTC 2013 | |
dc.date.issued | 2013-09-01 | |
dc.description.abstract | <p>The CmeABC efflux pump in Campylobacter jejuni confers resistance to structurally divergent antimicrobials, and inhibition of CmeABC represents a promising strategy to control antibiotic-resistant Campylobacter. Antisense peptide nucleic acids (PNAs) targeting the three components of CmeABC were evaluated for inhibition of CmeABC expression. The result revealed a synergistic effect of the PNAs targeting CmeA and CmeB on sensitizing C. jejuni to antibiotics. This finding further demonstrates the feasibility of using PNAs to potentiate antibiotics against antibiotic-resistant Campylobacter.</p> | |
dc.description.comments | <p>This article is published as Mu, Yang, Zhangqi Shen, Byeonghwa Jeon, Lei Dai, and Qijing Zhang. "Synergistic effects of anti-CmeA and anti-CmeB peptide nucleic acids on sensitizing Campylobacter jejuni to antibiotics." Antimicrobial agents and chemotherapy 57, no. 9 (2013): 4575-4577. doi: <a href="http://dx.doi.org/10.1128/AAC.00605-13%20" target="_blank" title="Synergistic Effects of Anti-CmeA and Anti-CmeB Peptide Nucleic Acids on Sensitizing Campylobacter jejuni to Antibiotics ">10.1128/AAC.00605-13</a>. Posted with permission.</p> | |
dc.format.mimetype | application/pdf | |
dc.identifier | archive/lib.dr.iastate.edu/vmpm_pubs/157/ | |
dc.identifier.articleid | 1156 | |
dc.identifier.contextkey | 10823940 | |
dc.identifier.s3bucket | isulib-bepress-aws-west | |
dc.identifier.submissionpath | vmpm_pubs/157 | |
dc.identifier.uri | https://dr.lib.iastate.edu/handle/20.500.12876/92262 | |
dc.language.iso | en | |
dc.source.bitstream | archive/lib.dr.iastate.edu/vmpm_pubs/157/2013_Zhang_SynergisticEffects.pdf|||Fri Jan 14 20:45:14 UTC 2022 | |
dc.source.uri | 10.1128/AAC.00605-13 | |
dc.subject.disciplines | Genetics and Genomics | |
dc.subject.disciplines | Molecular Genetics | |
dc.subject.disciplines | Veterinary Microbiology and Immunobiology | |
dc.subject.disciplines | Veterinary Preventive Medicine, Epidemiology, and Public Health | |
dc.title | Synergistic Effects of Anti-CmeA and Anti-CmeB Peptide Nucleic Acids on Sensitizing Campylobacter jejuni to Antibiotics | |
dc.type | article | |
dc.type.genre | article | |
dspace.entity.type | Publication | |
relation.isAuthorOfPublication | 1c6a5dfc-c604-457f-85be-122910db782e | |
relation.isOrgUnitOfPublication | 16f8e472-b1cd-4d8f-b016-09e96dbc4d83 |
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