Synergistic Effects of Anti-CmeA and Anti-CmeB Peptide Nucleic Acids on Sensitizing Campylobacter jejuni to Antibiotics

dc.contributor.author Mu, Yang
dc.contributor.author Shen, Zhangqi
dc.contributor.author Zhang, Qijing
dc.contributor.author Jeon, Byeonghwa
dc.contributor.author Dai, Lei
dc.contributor.author Zhang, Qijing
dc.contributor.department Veterinary Microbiology and Preventive Medicine
dc.date 2018-02-18T23:25:42.000
dc.date.accessioned 2020-07-07T05:14:39Z
dc.date.available 2020-07-07T05:14:39Z
dc.date.copyright Tue Jan 01 00:00:00 UTC 2013
dc.date.issued 2013-09-01
dc.description.abstract <p>The CmeABC efflux pump in Campylobacter jejuni confers resistance to structurally divergent antimicrobials, and inhibition of CmeABC represents a promising strategy to control antibiotic-resistant Campylobacter. Antisense peptide nucleic acids (PNAs) targeting the three components of CmeABC were evaluated for inhibition of CmeABC expression. The result revealed a synergistic effect of the PNAs targeting CmeA and CmeB on sensitizing C. jejuni to antibiotics. This finding further demonstrates the feasibility of using PNAs to potentiate antibiotics against antibiotic-resistant Campylobacter.</p>
dc.description.comments <p>This article is published as Mu, Yang, Zhangqi Shen, Byeonghwa Jeon, Lei Dai, and Qijing Zhang. "Synergistic effects of anti-CmeA and anti-CmeB peptide nucleic acids on sensitizing Campylobacter jejuni to antibiotics." Antimicrobial agents and chemotherapy 57, no. 9 (2013): 4575-4577. doi: <a href="http://dx.doi.org/10.1128/AAC.00605-13%20" target="_blank" title="Synergistic Effects of Anti-CmeA and Anti-CmeB Peptide Nucleic Acids on Sensitizing Campylobacter jejuni to Antibiotics ">10.1128/AAC.00605-13</a>. Posted with permission.</p>
dc.format.mimetype application/pdf
dc.identifier archive/lib.dr.iastate.edu/vmpm_pubs/157/
dc.identifier.articleid 1156
dc.identifier.contextkey 10823940
dc.identifier.s3bucket isulib-bepress-aws-west
dc.identifier.submissionpath vmpm_pubs/157
dc.identifier.uri https://dr.lib.iastate.edu/handle/20.500.12876/92262
dc.language.iso en
dc.source.bitstream archive/lib.dr.iastate.edu/vmpm_pubs/157/2013_Zhang_SynergisticEffects.pdf|||Fri Jan 14 20:45:14 UTC 2022
dc.source.uri 10.1128/AAC.00605-13
dc.subject.disciplines Genetics and Genomics
dc.subject.disciplines Molecular Genetics
dc.subject.disciplines Veterinary Microbiology and Immunobiology
dc.subject.disciplines Veterinary Preventive Medicine, Epidemiology, and Public Health
dc.title Synergistic Effects of Anti-CmeA and Anti-CmeB Peptide Nucleic Acids on Sensitizing Campylobacter jejuni to Antibiotics
dc.type article
dc.type.genre article
dspace.entity.type Publication
relation.isAuthorOfPublication 1c6a5dfc-c604-457f-85be-122910db782e
relation.isOrgUnitOfPublication 16f8e472-b1cd-4d8f-b016-09e96dbc4d83
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