Synergistic Effects of Anti-CmeA and Anti-CmeB Peptide Nucleic Acids on Sensitizing Campylobacter jejuni to Antibiotics

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dc.contributor.author Mu, Yang
dc.contributor.author Shen, Zhangqi
dc.contributor.author Jeon, Byeonghwa
dc.contributor.author Dai, Lei
dc.contributor.author Zhang, Qijing
dc.contributor.department Veterinary Microbiology and Preventive Medicine
dc.date 2018-02-18T23:25:42.000
dc.date.accessioned 2020-07-07T05:14:39Z
dc.date.available 2020-07-07T05:14:39Z
dc.date.copyright Tue Jan 01 00:00:00 UTC 2013
dc.date.issued 2013-09-01
dc.description.abstract <p>The CmeABC efflux pump in Campylobacter jejuni confers resistance to structurally divergent antimicrobials, and inhibition of CmeABC represents a promising strategy to control antibiotic-resistant Campylobacter. Antisense peptide nucleic acids (PNAs) targeting the three components of CmeABC were evaluated for inhibition of CmeABC expression. The result revealed a synergistic effect of the PNAs targeting CmeA and CmeB on sensitizing C. jejuni to antibiotics. This finding further demonstrates the feasibility of using PNAs to potentiate antibiotics against antibiotic-resistant Campylobacter.</p>
dc.description.comments <p>This article is published as Mu, Yang, Zhangqi Shen, Byeonghwa Jeon, Lei Dai, and Qijing Zhang. "Synergistic effects of anti-CmeA and anti-CmeB peptide nucleic acids on sensitizing Campylobacter jejuni to antibiotics." Antimicrobial agents and chemotherapy 57, no. 9 (2013): 4575-4577. doi: <a href="http://dx.doi.org/10.1128/AAC.00605-13%20" target="_blank" title="Synergistic Effects of Anti-CmeA and Anti-CmeB Peptide Nucleic Acids on Sensitizing Campylobacter jejuni to Antibiotics ">10.1128/AAC.00605-13</a>. Posted with permission.</p>
dc.format.mimetype application/pdf
dc.identifier archive/lib.dr.iastate.edu/vmpm_pubs/157/
dc.identifier.articleid 1156
dc.identifier.contextkey 10823940
dc.identifier.s3bucket isulib-bepress-aws-west
dc.identifier.submissionpath vmpm_pubs/157
dc.identifier.uri https://dr.lib.iastate.edu/handle/20.500.12876/92262
dc.language.iso en
dc.source.bitstream archive/lib.dr.iastate.edu/vmpm_pubs/157/2013_Zhang_SynergisticEffects.pdf|||Fri Jan 14 20:45:14 UTC 2022
dc.source.uri 10.1128/AAC.00605-13
dc.subject.disciplines Genetics and Genomics
dc.subject.disciplines Molecular Genetics
dc.subject.disciplines Veterinary Microbiology and Immunobiology
dc.subject.disciplines Veterinary Preventive Medicine, Epidemiology, and Public Health
dc.title Synergistic Effects of Anti-CmeA and Anti-CmeB Peptide Nucleic Acids on Sensitizing Campylobacter jejuni to Antibiotics
dc.type article
dc.type.genre article
dspace.entity.type Publication
relation.isAuthorOfPublication 1c6a5dfc-c604-457f-85be-122910db782e
relation.isOrgUnitOfPublication 16f8e472-b1cd-4d8f-b016-09e96dbc4d83
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