Effect of amlodipine on the circulating renin-angiotensin-aldosterone system in healthy cats
Date
2024-02-09
Authors
Marrero, Tatiana M. Garcia
Tropf, Melissa A.
Bourgois-Mochel, Agnes
Guillot, Emilie
Domenig, Oliver
Yuan, Lingnan
Kundu, Debosmita
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Wiley Periodicals LLC on behalf of American College of Veterinary Internal Medicine.
Abstract
Background: Systemic hypertension (SH) is a common cardiovascular disease in older cats that is treated primarily with the calcium channel blocker amlodipine besylate (AML). The systemic effect of AML on the classical and alterative arms of the renin-angiotensin-aldosterone system (RAAS) in cats is incompletely characterized.Hypothesis/Objectives: To determine the effect of AML compared to placebo on circulating RAAS biomarkers in healthy cats using RAAS fingerprinting. Animals: Twenty healthy client-owned cats. Methods: Cats were administered amlodipine besylate (0.625 mg in toto) or placebo by mouth once daily for 14 days in a crossover design with a 4-week washout period. Plasma AML concentrations and RAAS biomarker concentrations were measured at multiple timepoints after the final dose in each treatment period. Time-weighted averages for RAAS biomarkers over 24 hours after dosing were compared between treatment groups using Wilcoxon rank-sum testing. Results: Compared to placebo, AML treatment was associated with increases in markers of plasma renin concentration (median 44% increase; interquartile range [IQR] 19%-86%; P = .009), angiotensin I (59% increase; IQR 27-101%; P = .006), angiotensin II (56% increase; IQR 5-70%; P = .023), angiotensin IV (42% increase; −19% to 89%; P = .013); and angiotensin 1-7 (38% increase; IQR 9-118%; P = .015). Conclusions and Clinical Importance: In healthy cats, administration of AML resulted in nonspecific activation of both classical and alternative RAAS pathways.
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This article is published as Garcia Marrero, Tatiana M., Jessica L. Ward, Melissa A. Tropf, Agnes Bourgois‐Mochel, Emilie Guillot, Oliver Domenig, Lingnan Yuan, Debosmita Kundu, and Jonathan P. Mochel. "Effect of amlodipine on the circulating renin‐angiotensin‐aldosterone system in healthy cats." Journal of Veterinary Internal Medicine (2024). doi: https://doi.org/10.1111/jvim.17006. © 2024 The Authors. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs.