Using Biomaterials to Reduce Fibrous Encapsulation of Biomedical Implants

Date
2015-04-14
Authors
Le Denmat, Catherine
Major Professor
Advisor
Committee Member
Journal Title
Journal ISSN
Volume Title
Publisher
Altmetrics
Authors
Research Projects
Organizational Units
Journal Issue
Series
Department
Materials Science and Engineering
Abstract

Fibrous encapsulation, commonly referred to as scar formation, can cause failure in many biomedical implants, such as in the artificial pancreas for type I diabetes treatment. Scar tissue prevents wastes and nutrients from being able to be exchanged in the implant, ultimately rendering the treatment painful or ineffective. For example, one potential therapeutic for type I diabetes involves using a polymer to protect insulin-producing cells. This artificial pancreas provides diabetics with their much needed insulin on-demand. If scar tissue forms around this artificial pancreas, the device loses the ability to deliver insulin and becomes useless. Our goal is to reduce the fibrous encapsulation of implants using biomaterials and improve the understanding of how cells involved in scar formation respond to biomaterials. We show that our materials can reduce fibrous capsule formation by inhibiting certain physiological pathways. This research will not only improve the success of the artificial pancreas, but other biomaterials.

Comments
Description
Keywords
Citation
DOI
Source