Echinacea tennesseensis ethanol tinctures harbor cytokine- and proliferation-enhancing capacities Senchina, David McCann, Dustin Flinn, Gina Wu, Lankun Wurtele, Eve Zhai, Zili Cunnick, Joan Wurtele, Eve Kohut, Marian
dc.contributor.department Animal Science
dc.contributor.department Kinesiology
dc.contributor.department Genetics, Development and Cell Biology 2018-02-18T04:19:59.000 2020-06-30T04:02:45Z 2020-06-30T04:02:45Z Thu Jan 01 00:00:00 UTC 2009 2009-01-01
dc.description.abstract <p>Background—Members of the genus Echinacea are used medicinally to treat upper respiratory infections such as colds and influenza. The aim of the present investigation was to characterize the phytomedicinal properties of the American federally endangered species Echinacea tennesseensis.</p> <p>Methods—Fifty-percent ethanol tinctures were prepared from roots, stems, leaves, and flowers and tested separately for their ability to influence production of IL-1β, IL-2, IL-10, and TNF-α as well as proliferation by young human adult peripheral blood mononuclear cells (PMBC) in vitro. Tincture aliquots were stored at three different temperatures (4°, −20°C, and −80°C) for 21 h before testing. At one-month post-extraction, tinctures stored at −20°C were tested again for cytokine modulation. Phytochemical analyses were performed using HPLC.</p> <p>Results—Fresh root, leaf, and flower tinctures stimulated PBMC proliferation. Fresh root tinctures alone stimulated IL-1β, IL-10, and TNF-α production. No tinctures modulated IL-2 production. Stem tinctures showed no activity. Storage temperature did not influence any outcomes. Root tinctures maintained their ability to modulate IL-1β, IL-10, and TNF-α production after one month of storage at −20°C.</p> <p>Conclusions—These results suggest E. tennesseensis harbors phytomedicinal properties that vary by plant organ, with roots demonstrating the strongest activities.</p>
dc.description.comments <p>This is a manuscript of an article from <em>Cytokine </em>46 (2009): 267, doi: <a href="" id="x-ddDoi">10.1016/j.cyto.2009.02.007</a>. Posted with permission.</p>
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dc.identifier archive/
dc.identifier.articleid 1075
dc.identifier.contextkey 9661259
dc.identifier.s3bucket isulib-bepress-aws-west
dc.identifier.submissionpath gdcb_las_pubs/74
dc.language.iso en
dc.source.bitstream archive/|||Sat Jan 15 01:47:35 UTC 2022
dc.source.uri 10.1016/j.cyto.2009.02.007
dc.subject.disciplines Animal Sciences
dc.subject.disciplines Cell and Developmental Biology
dc.subject.disciplines Genetics and Genomics
dc.subject.disciplines Kinesiology
dc.subject.keywords Echinacea tennessensis
dc.subject.keywords tincture
dc.subject.keywords cytokine
dc.title Echinacea tennesseensis ethanol tinctures harbor cytokine- and proliferation-enhancing capacities
dc.type article
dc.type.genre article
dspace.entity.type Publication
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