Cytokine responses across submaximal exercise intensities in women with major depressive disorder

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dc.contributor.author Perez, Maria
dc.contributor.author Meyer, Jacob
dc.contributor.author Raison, Charles
dc.contributor.author Coe, Christopher
dc.contributor.author Cook, Dane
dc.contributor.author Meyer, Jacob
dc.contributor.department Kinesiology
dc.date 2021-01-28T02:00:34.000
dc.date.accessioned 2021-02-26T02:28:58Z
dc.date.available 2021-02-26T02:28:58Z
dc.date.copyright Wed Jan 01 00:00:00 UTC 2020
dc.date.issued 2020-02-01
dc.description.abstract <p>Background Major depressive disorder (MDD) is associated with chronic inflammation. Exercise training can treat depression in adults with MDD, potentially through reducing inflammatory activity. This improvement may occur through adaptations to repeated acute inflammatory responses. Cytokine responses to acute steady-state exercise of varying intensities were determined in women with different levels of depression.</p> <p>Methods This analysis included 19 women with MDD who each participated in four sessions consisting of 30 min of quiet rest, light, moderate, or hard intensity exercise. Blood samples were collected pre- and within 10 min post-session. Changes in the levels of IL-6, IL-8, IL-10, and TNF were evaluated in each session.</p> <p>Results Serum concentrations of IL-6, IL-8 and TNF were all significantly elevated following vigorous exercise (i.e., hard) compared to the quiet rest session. No changes in cytokine levels occurred after light and moderate exercise. Depression severity did not appear to influence the acute inflammatory response to exercise.</p> <p>Limitations The sample size was small, all female, and from a secondary data analysis, which limits the generalizability of the findings.</p> <p>Conclusions Repeat, acute increases in inflammatory activity following hard exercise sessions may prompt adaptations and lead to reductions in chronic inflammation over time. This dose-response study identified an exercise intensity threshold to induce acute inflammatory responses in women with MDD.</p>
dc.description.comments <p>This article is published as Perez, M.L., Raison, C.L., Coe. C.L., Cook, D.B., Meyer, J.D., Cytokine responses across submaximal exercise intensities in women with major depressive disorder. <em>Brain, behavior, & Immunity – Health. </em>February 2020, 2; 100046. Doi: <a href="https://doi.org/10.1016/j.bbih.2020.100046" target="_blank" title="Persistent link using digital object identifier">10.1016/j.bbih.2020.100046</a>. </p>
dc.format.mimetype application/pdf
dc.identifier archive/lib.dr.iastate.edu/kin_pubs/88/
dc.identifier.articleid 1088
dc.identifier.contextkey 21293771
dc.identifier.s3bucket isulib-bepress-aws-west
dc.identifier.submissionpath kin_pubs/88
dc.identifier.uri https://dr.lib.iastate.edu/handle/20.500.12876/96556
dc.language.iso en
dc.source.bitstream archive/lib.dr.iastate.edu/kin_pubs/88/2020_MeyerJ_Cytokine_responses_across_submaximal.pdf|||Sat Jan 15 02:17:22 UTC 2022
dc.source.uri 10.1016/j.bbih.2020.100046
dc.subject.disciplines Exercise Science
dc.subject.disciplines Kinesiology
dc.subject.disciplines Psychiatric and Mental Health
dc.subject.disciplines Psychology of Movement
dc.subject.keywords Major depressive disorder
dc.subject.keywords Inflammation
dc.subject.keywords Exercise
dc.subject.keywords Cytokines
dc.subject.keywords Dose-response
dc.subject.keywords Interleukin
dc.title Cytokine responses across submaximal exercise intensities in women with major depressive disorder
dc.type article
dc.type.genre article
dspace.entity.type Publication
relation.isAuthorOfPublication 6d25a191-dd56-4965-a726-6dfe139e771a
relation.isOrgUnitOfPublication f7b0f2ca-8e43-4084-8a10-75f62e5199dd
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