Constitutive and Inducible Expression of the rRNA Methylase Gene erm(B) in Campylobacter

Date
2015-10-01
Authors
Deng, Fengru
Shen, Jianzhong
Zhang, Qijing
Zhang, Maojun
Wu, Congming
Zhang, Qijing
Wang, Yang
Major Professor
Advisor
Committee Member
Journal Title
Journal ISSN
Volume Title
Publisher
Altmetrics
Authors
Research Projects
Organizational Units
Journal Issue
Series
Department
Veterinary Microbiology and Preventive Medicine
Abstract

Macrolides are the antimicrobials of choice for treating human campylobacteriosis. The recent emergence of erm(B) in Campylobacter bacteria threatens the utility of this class of antibiotics. Here we report the constitutive and inducible expression of erm(B) in Campylobacter isolates derived from diarrheal patients and food-producing animals. Constitutive expression of erm(B) was associated with insertion and deletion in the regulatory region of the gene, providing the first documentation of the differential expression of erm(B) in Campylobacter bacteria.

Comments

This article is published as Deng, Fengru, Jianzhong Shen, Maojun Zhang, Congming Wu, Qijing Zhang, and Yang Wang. "Constitutive and inducible expression of the rRNA methylase gene erm (B) in Campylobacter." Antimicrobial agents and chemotherapy 59, no. 10 (2015): 6661-6664. doi: 10.1128/AAC.01103-15. Posted with permission.

Description
Keywords
Citation
DOI
Collections