Constitutive and Inducible Expression of the rRNA Methylase Gene erm(B) in Campylobacter
Macrolides are the antimicrobials of choice for treating human campylobacteriosis. The recent emergence of erm(B) in Campylobacter bacteria threatens the utility of this class of antibiotics. Here we report the constitutive and inducible expression of erm(B) in Campylobacter isolates derived from diarrheal patients and food-producing animals. Constitutive expression of erm(B) was associated with insertion and deletion in the regulatory region of the gene, providing the first documentation of the differential expression of erm(B) in Campylobacter bacteria.
This article is published as Deng, Fengru, Jianzhong Shen, Maojun Zhang, Congming Wu, Qijing Zhang, and Yang Wang. "Constitutive and inducible expression of the rRNA methylase gene erm (B) in Campylobacter." Antimicrobial agents and chemotherapy 59, no. 10 (2015): 6661-6664. doi: 10.1128/AAC.01103-15. Posted with permission.