A number of factors influenced the record crop in Iowa during 2004. While weed control was generally good, the cool and wet conditions enhanced potential injury from a number of herbicides. Furthermore, with increase adoption of transgenic glyphosate resistant corn and soybean, changes in weed populations, either weed population shifts or the evolution of resistant weeds, must be given due consideration for a successful 2005 growing season. The paper will describe some of the issues and opportunities facing Iowa growers in the next growing season.