Identifying Chromosomal Recombinations in Beef Cattle from Genotyped Parent-Offspring Pairs

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2014-01-01
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Weng, Ziqing
Garrick, Dorian
Saatchi, Mahdi
Schnabel, Robert
Taylor, Jeremy
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Abstract

This study investigated meiotic recombination in two breeds of cattle by comparing phased SNP haplotypes in sire-offspring pairs. The positions and number of recombination events were identified. The number of recombination events varies between individuals and is a heritable trait. A genome-wide association analysis identified quantitative trait loci (QTL) associated with variation in the number of recombination events. Regions that had more recombination events than expected were identified in both breeds, and many of these hotspots were in common. Recombination is important biologically because it is the mechanism for reassembling paternal and maternal alleles. Recombination impacts the accuracy of imputation, a commonly-used approach to infer the genotypes of some individuals based on genotypes of others.

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Animal Science Research Reports
ASL R2845
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report
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Wed Jan 01 00:00:00 UTC 2014
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