Organelle aging: Lessons from model organisms

Date
2019-04-20
Authors
Bouska, Mark
Huang, Kerui
Kang, Ping
Bai, Hua
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Bai, Hua
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Abstract

Most cellular processes descend into failure during aging. While a large collection of longevity pathways has been identified in the past decades, the mechanism for age-related decline of cellular homeostasis and organelle function remains largely unsolved. It is known that many organelles undergo structural and functional changes during normal aging, which significantly contributes to the decline of tissue function at old ages. Since recent studies have revealed an emerging role of organelles as regulatory hubs in maintaining cellular homeostasis, understanding of organelle aging will provide important insights into the cellular basis of organismal aging. Here we review current progress on the characterization of age-dependent structural and functional alterations in the more well-studied organelles, as well as the known mechanisms governing organelle aging in model organisms, with a special focus on the fruit fly Drosophila melanogaster.

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This is a manuscript of an article published as Bouska, Mark, Kerui Huang, Ping Kang, and Hua Bai. "Organelle aging: Lessons from model organisms." Journal of Genetics and Genomics 46 (2019): 171-185. doi: 10.1016/j.jgg.2019.03.011. Posted with permission.

Keywords
Longevity, Mitochondria, Nucleus, Autophagosome, Lysosome, Proteasome, Cell membrane
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