Folic acid source, usual intake, and folate and vitamin B-12 status in US adults: National Health and Nutrition Examination Survey (NHANES) 2003–2006
dc.contributor.author | Yang, Quanhe | |
dc.contributor.author | Cogswell, Mary | |
dc.contributor.author | Hamner, Heather | |
dc.contributor.author | Carriquiry, Alicia | |
dc.contributor.author | Pfeiffer, Christine | |
dc.contributor.author | Berry, Robert | |
dc.contributor.department | Statistics (LAS) | |
dc.date | 2018-02-17T06:24:33.000 | |
dc.date.accessioned | 2020-07-02T06:57:49Z | |
dc.date.available | 2020-07-02T06:57:49Z | |
dc.date.issued | 2010-01-01 | |
dc.description.abstract | <p>Background: US adults have access to multiple sources of folic acid. The contribution of these sources to usual intakes above the tolerable upper intake level (UL) (1000 ug/d) and to folate and vitamin B-12 status is unknown. Objective: The objective was to estimate usual folic acid intake above the UL and adjusted serum and red blood cell folate, vitamin B-12, methylmalonic acid, and homocysteine concentrations among US adults by 3 major folic acid intake sources - enriched cereal-grain products (ECGP), ready-to-eat cereals (RTE), and supplements (SUP) - categorized into 4 mutually exclusive consumption groups. Design: We used data from the National Health and Nutrition Examination Survey (NHANES) 2003-2006 (n = 8258). Results: Overall, 2.7% (95% CI: 1.9%, 3.5%) of adults consumed more than the UL of folic acid. The proportions of those who consumed folic acid from ECGP only, ECGP+RTE, ECGP+SUP, and ECGP+RTE+SUP were 42%, 18%, 25%, and 15%, respectively. Of 60% of adults who did not consume supplements containing folic acid (ECGP only and ECGP+RTE), 0% had intakes that exceeded the UL. Of 34% and 6% of adults who consumed supplements with an average of <400 and >400 ug folic acid/d, <1% and 47.8% (95% CI: 39.6%, 56.0%), respectively, had intakes that exceeded the UL. Consumption of RTE and/or supplements with folic acid was associated with higher folate and vitamin B-12 and lower homocysteine concentrations, and consumption of supplements with vitamin B-12 was associated with lower methylmalonic acid concentrations (P < 0.001). Conclusion: At current fortification levels, US adults who do not consume supplements or who consume an average of <400 ug folic acid/d from supplements are unlikely to exceed the UL in intake for folic acid.</p> | |
dc.description.comments | <p>This article is from <em>American Journal of Clinical Nutrition</em> 91 (2010): 64, doi: <a href="http://dx.doi.org/10.3945/ajcn.2009.28401" target="_blank">10.3945/ajcn.2009.28401</a>.</p> | |
dc.format.mimetype | application/pdf | |
dc.identifier | archive/lib.dr.iastate.edu/stat_las_pubs/36/ | |
dc.identifier.articleid | 1037 | |
dc.identifier.contextkey | 7858748 | |
dc.identifier.s3bucket | isulib-bepress-aws-west | |
dc.identifier.submissionpath | stat_las_pubs/36 | |
dc.identifier.uri | https://dr.lib.iastate.edu/handle/20.500.12876/90633 | |
dc.language.iso | en | |
dc.source.bitstream | archive/lib.dr.iastate.edu/stat_las_pubs/36/2010_CarriquiryAL_FolicAcidSource.pdf|||Fri Jan 14 23:46:38 UTC 2022 | |
dc.source.uri | 10.3945/ajcn.2009.28401 | |
dc.subject.disciplines | Biochemical Phenomena, Metabolism, and Nutrition | |
dc.subject.disciplines | Public Health | |
dc.subject.disciplines | Statistics and Probability | |
dc.subject.keywords | cyanocobalamin | |
dc.subject.keywords | folic acid | |
dc.subject.keywords | homocysteine | |
dc.subject.keywords | methylmalonic acid | |
dc.subject.keywords | child nutrition | |
dc.subject.keywords | diet supplementation | |
dc.subject.keywords | dietary intake | |
dc.subject.keywords | health survey | |
dc.title | Folic acid source, usual intake, and folate and vitamin B-12 status in US adults: National Health and Nutrition Examination Survey (NHANES) 2003–2006 | |
dc.type | article | |
dc.type.genre | article | |
dspace.entity.type | Publication | |
relation.isAuthorOfPublication | 6ddd5891-2ad0-4a93-89e5-8c35c28b0de4 | |
relation.isOrgUnitOfPublication | 264904d9-9e66-4169-8e11-034e537ddbca |
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