The Regulatory Status of Genome-edited Crops

dc.contributor.author Wolt, Jeffrey
dc.contributor.author Wang, Kan
dc.contributor.author Yang, Bing
dc.contributor.department Agronomy
dc.contributor.department Genetics, Development and Cell Biology
dc.contributor.department Plant Biology
dc.date 2018-02-17T15:15:39.000
dc.date.accessioned 2020-06-29T23:07:10Z
dc.date.available 2020-06-29T23:07:10Z
dc.date.copyright Thu Jan 01 00:00:00 UTC 2015
dc.date.issued 2016-02-01
dc.description.abstract <p>Genome editing with engineered nucleases (GEEN) represents a highly specific and efficient tool for crop improvement with the potential to rapidly generate useful novel phenotypes/traits. Genome editing techniques initiate specifically targeted double strand breaks facilitating DNA-repair pathways that lead to base additions or deletions by non-homologous end joining as well as targeted gene replacements or transgene insertions involving homology-directed repair mechanisms. Many of these techniques and the ancillary processes they employ generate phenotypic variation that is indistinguishable from that obtained through natural means or conventional mutagenesis; and therefore, they do not readily fit current definitions of genetically engineered or genetically modified used within most regulatory regimes. Addressing ambiguities regarding the regulatory status of genome editing techniques is critical to their application for development of economically useful crop traits. Continued regulatory focus on the process used, rather than the nature of the novel phenotype developed, results in confusion on the part of regulators, product developers, and the public alike and creates uncertainty as of the use of genome engineering tools for crop improvement.</p>
dc.description.comments <p>This article is from <em>Plant Biotechnology Journal</em> 14 (2015): 510–518, doi:<a href="http://dx.doi.org/10.1111/pbi.12444" target="_blank">10.1111/pbi.12444</a>. Posted with permission.</p>
dc.format.mimetype application/pdf
dc.identifier archive/lib.dr.iastate.edu/agron_pubs/95/
dc.identifier.articleid 1095
dc.identifier.contextkey 8386648
dc.identifier.s3bucket isulib-bepress-aws-west
dc.identifier.submissionpath agron_pubs/95
dc.identifier.uri https://dr.lib.iastate.edu/handle/20.500.12876/5069
dc.language.iso en
dc.source.bitstream archive/lib.dr.iastate.edu/agron_pubs/95/2016_Wolt_RegulatoryStatus.pdf|||Sat Jan 15 02:33:55 UTC 2022
dc.source.uri 10.1111/pbi.12444
dc.subject.disciplines Agricultural Science
dc.subject.disciplines Agriculture
dc.subject.disciplines Agronomy and Crop Sciences
dc.subject.disciplines Genomics
dc.subject.disciplines Plant Breeding and Genetics
dc.subject.keywords engineered nucleases
dc.subject.keywords site-specific mutagenesis
dc.subject.keywords site-directed nucleases
dc.subject.keywords homology-directed repair
dc.subject.keywords CRISPR/Cas9
dc.subject.keywords TALEN
dc.title The Regulatory Status of Genome-edited Crops
dc.type article
dc.type.genre article
dspace.entity.type Publication
relation.isOrgUnitOfPublication fdd5c06c-bdbe-469c-a38e-51e664fece7a
relation.isOrgUnitOfPublication 9e603b30-6443-4b8e-aff5-57de4a7e4cb2
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