Sanguinarine, a quaternary benzophenanthridine alkaloid plant extract of Macleya cordata, has demonstrated to have anti-inflammatory, antimicrobial and immunomodulatory effect. It increases the availability of aromatic amino acids and decreases the levels of toxic biogenic amines. This study was aimed to evaluate the effect of Sangrovit® supplementation as compared to tylosin on growth performance, feed efficiency and Lawsonia intracellularis shedding in pigs, and to determine the effect of Sangrovit® on the immune system. A total of 24 pigs, four weeks-old challenged with Lawsonia intracellularis were randomly allocated to a treatment group (control non-supplemented, 40 g Sangrovit®/mton, 75 g Sangrovit®/mton, and 22g /kg tylosin). Pigs were weighed weekly and average daily gain (ADG), average daily feed intake (ADFI) and gain to feed ratio (G:F) were calculated.