Enhancing binding affinity and selectivity through preorganization and cooperative enhancement of the receptor
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2016-01-01
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Gunasekara, Roshan
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Abstract
When direct host–guest binding interactions are weakened by unfavorable solvent competition, guest-triggered intrareceptor interactions could be used to augment the binding. This strategy of cooperative enhancement, when combined with the principle of preorganization, yielded a strong and selective receptor for binding citrate in water.
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This is a manuscript of an article published as Gunasekara, Roshan W., and Yan Zhao. "Enhancing binding affinity and selectivity through preorganization and cooperative enhancement of the receptor." Chemical Communications 52, no. 23 (2016): 4345-4348. DOI: 10.1039/C5CC10405J. Posted with permission.
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Fri Jan 01 00:00:00 UTC 2016