Semi-active and active structural control systems are advanced mechanical devices and systems capable of high damping performance, ideal for mitigation of multi-hazards. The implementation of these devices within structural systems is still in its infancy, because of the complexity in designing a robust closed-loop control system that can ensure reliable and high mitigation performance. Particular challenges in designing a controller for multi-hazard mitigation include: 1) very large uncertainties on dynamic parameters and unknown excitations; 2) limited measurements with probabilities of sensor failure; 3) immediate performance requirements; and 4) unavailable sets of input-output during design. To facilitate the implementation of structural control systems, a new type of controllers with high adaptive capabilities is proposed. It is based on real-time identification of an embedding that represents the essential dynamics found in the input space, or in the sensors measurements. This type of controller is termed input-space dependent controllers (ISDC). In this paper, the principle of ISDC is presented, their stability and performance derived analytically for the case of harmonic inputs, and their performance demonstrated in the case of different types of hazards. Results show the promise of this new type of controller at mitigating multi-hazards by 1) relying on local and limited sensors only; 2) not requiring prior evaluation or training; and 3) adapting to systems non-stationarities.