Dynamic evolution of terpenoid biosynthesis in the Lamiaceae
Date
2023-06-05
Authors
Wang, Zhibiao
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Cell Press
Abstract
With the increasing accessibility of whole-genome sequencing, it has become standard practice to apply such an approach to investigation of plants with important and/or interesting natural products. In part, this reflects recognition that plants have occasionally rearranged or shuffled their genes to generate biosynthetic gene clusters (BGCs) for certain natural products (Smit and Lichman, 2022; Zhan et al., 2022). Use of such a genome-sequence based ‘reverse-genetics’ approach to BGC discovery was first demonstrated in rice (Oryza sativa), particularly for diterpenoid production, enabling relatively rapid progress towards elucidation of the underlying metabolic network (Wang et al., 2023). Accordingly, discovery of an associated BGC is expected to enable more facile investigation of the relevant biosynthetic pathway for the targeted natural product (Zhan et al., 2022). However, it must be noted that plant metabolic evolution is not constrained by BGCs, as the associated pathways often rely on enzymes whose genes are not co-localized (Smit and Lichman, 2022). Indeed, it has been reported that co-expression is a more reliable signal of common biosynthetic function (Wisecaver et al., 2017).
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This is a manuscript of an article published as Wang, Zhibiao, and Reuben J. Peters. "Dynamic evolution of terpenoid biosynthesis in the Lamiaceae." Molecular Plant 16, no. 6 (2023): 963-965. doi:10.1016/j.molp.2023.04.012. © 2023 The Author. This manuscript is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License. Posted with permission.