Countrywide, harmonized microbiological resistance monitoring of indicator Escherichia coli isolated from healthy pigs at slaughter wasrun in 2009 and 2010. Resistance to each of the 13 tested antimicrobials was found, reaching a maximum value of 40%in the case of streptomycin and tetracycline. Cephalosporin resistance was sparse andless than 10% of strains possessed quinolone resistance. Numerous resistance profiles comprised up to 11 compounds from 7 antimicrobial classes. Year-to-year trendsin resistance were not significant, with the exception of the decrease of the number of non-resistant strains (P≤0,05). The most frequent resistances correlate with the consumption of antimicrobials used for swine treatment. The results justified the need for continuous resistance monitoring followed by study on genetic background of the resistance. The attention is also drawn to the public health impact including possible therapeutic failures with drugs critically important for human medicine.