Abnormal Presentation of Feline Congenital Hypothyroidism
Date
2020-12
Authors
Kay, Erin
Major Professor
Advisor
Ellinwood, Matthew
Smith, Jodi
Committee Member
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Abstract
The aim of this study was to identify the causative allelic change that resulted in the atypical form of congenital hypothyroidism noted within a feline research breeding colony used to study glaucoma. Retrospective analysis of archival records as well as whole genome sequencing (WGS) of specific members of the breeding colony were performed. A pedigree was constructed to determine the inheritance pattern of the disease. It has been determined that the inheritance is polygenic. Simply put, the disease is not informed by a single gene as is evidenced by the inheritance denoted in the pedigree. Instead, the disease is inherited via multiple genes working in conjunction with each other. This study pointed to the disease inheritance being partially x-linked as well as likely having qualities of permissiveness. The results of the study have been sent to Dr. Leslie Lyons, an associate professor at the University of Missouri, to be studied further.
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