Self-Immolative Aryl Phthalate Esters
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We report that aryl phthalate esters are robust self-immolative linkers. This linker is easy to conjugate and releases output phenols upon cleaving a fluoride-sensitive mask to yield a benign phthalic acid byproduct, making these linkers potentially useful as fluoride sensors and promising for use in biological and materials applications.
Reprinted (adapted) with permission from J. Org. Chem., 2013, 78 (2), pp 702–705. Copyright 2012 American Chemical Society.