Self-Immolative Aryl Phthalate Esters

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2013-01-01
Authors
Mahoney, Kaitlyn
Goswami, Pratik
Winter, Arthur
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Chemistry
Abstract

We report that aryl phthalate esters are robust self-immolative linkers. This linker is easy to conjugate and releases output phenols upon cleaving a fluoride-sensitive mask to yield a benign phthalic acid byproduct, making these linkers potentially useful as fluoride sensors and promising for use in biological and materials applications.

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Reprinted (adapted) with permission from J. Org. Chem., 2013, 78 (2), pp 702–705. Copyright 2012 American Chemical Society.

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Sun Jan 01 00:00:00 UTC 2012
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