Histotripsy Treatment of S. Aureus Biofilms on Surgical Mesh Samples Under Varying Scan Parameters

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Wu, Huaiqing
Itani, Kamal MF.
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Bigelow, Timothy
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Center for Nondestructive Evaluation

The Center for Nondestructive Evaluation at Iowa State has been involved in the use of nondestructive evaluation testing (NDT) technologies to: assess the integrity of a substance, material or structure; assess the criticality of any flaws, and to predict the object’s remaining serviceability. NDT technologies used include ultrasonics and acoustic emissions, electromagnetic technologies, computer tomography, thermal imaging, and others.

In October of 1985 the CNDE was approved by the State Board of Regents after it had received a grant from the National Science Foundation (NSF) as an Industry/University Cooperative Research Center.

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The Department of Statistics seeks to teach students in the theory and methodology of statistics and statistical analysis, preparing its students for entry-level work in business, industry, commerce, government, or academia.

The Department of Statistics was formed in 1948, emerging from the functions performed at the Statistics Laboratory. Originally included in the College of Sciences and Humanities, in 1971 it became co-directed with the College of Agriculture.

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Cavitation-based ultrasound histotripsy has shown potential for treating infections on surgical mesh. The goal of this paper was to explore a new scan strategy while assessing the impact of scan speed, scan step size, and the number of cycles in the tone burst on the destruction of S. aureus biofilms grown on surgical mesh samples using ultrasound histotripsy pulses (150 MPa/-17 MPa). For each exposure, the number of colony forming units (CFUs) on the mesh and released onto the surrounding gel was quantified. Most of the exposed mesh samples had no CFUs, and there was a statistically significant reduction in CFUs on the mesh for each of the exposures, with an average reduction of 3.8 log10 relative to the sham. Compared with the sham, there was also a statistically significant reduction in CFUs on the gel with the highest exposures.
This is a manuscript of an article published as Bigelow, Timothy A., Clayton L. Thomas, Huaiqing Wu, and Kamal MF Itani. "Histotripsy treatment of S. Aureus biofilms on surgical mesh samples under varying scan parameters." IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control 65, no. 6 (2018): 1017-1024. DOI: 10.1109/TUFFC.2018.2819363. Copyright 2018 IEEE. Personal use of this material is permitted. Permission from IEEE must be obtained for all other uses, in any current or future media, including reprinting/republishing this material for advertising or promotional purposes, creating new collective works, for resale or redistribution to servers or lists, or reuse of any copyrighted component of this work in other works. Posted with permission.