Genomic Analysis Suggests KITLG is Responsible for a Roan Pattern in two Pakistani Goat Breeds

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Talenti, Andrea
Bertolini, Francesca
Williams, Jamie
Moaeen-ud-Din, Muhammad
Frattini, Stefano
Coizet, Beatrice
Pagnacco, Giulio
Crepaldi, Paola
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Rothschild, Max
Distinguished Professor Emeritus
Reecy, James
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Animal Science

The Department of Animal Science originally concerned itself with teaching the selection, breeding, feeding and care of livestock. Today it continues this study of the symbiotic relationship between animals and humans, with practical focuses on agribusiness, science, and animal management.

The Department of Animal Husbandry was established in 1898. The name of the department was changed to the Department of Animal Science in 1962. The Department of Poultry Science was merged into the department in 1971.

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The roan coat color pattern is described as the presence of white hairs intermixed with pigmented hairs. This kind of pigmentation pattern has been observed in many domestic species, including the goat. The molecular mechanisms and inheritance that underlie this pattern are known for some species and the KITLG gene has been shown associated with this phenotype. To date, no research effort has been done to find the gene(s) that controls roan coat color pattern in goats. In the present study, after genotyping with the GoatSNP50 BeadChip, 35 goats that showed a roan pattern and that belonged to two Pakistan breeds (Group A) were analyzed and then compared to 740 goats of 39 Italian and Pakistan goats breeds that did not have the same coat color pattern (Group B). Run of homozygosity-based and XP-EHH analyses were used to identify unique genomic regions potentially associated with the roan pattern. A total of 3 regions on chromosomes 5, 6 and 12 were considered unique among the group A versus B group comparisons. The A region > 1.7 Mb on chromosome 5 was the most divergent between the two groups. This region contains six genes, including the KITLG gene. Our findings support the hypothesis that the KITLG gene may be associated with the roan phenotype in goats.


This is a pre-copyedited, author-produced version of an article accepted for publication in Journal of Heredity following peer review. The version of record Andrea Talenti, Francesca Bertolini, Jamie Williams, Muhammad Moaeen-ud-Din, Stefano Frattini, Beatrice Coizet, Giulio Pagnacco, James Reecy, Max F Rothschild, Paola Crepaldi, ; Genomic Analysis Suggests KITLG is Responsible for a Roan Pattern in two Pakistani Goat Breeds, Journal of Heredity (2017) is available online at: Posted with permission.

Sun Jan 01 00:00:00 UTC 2017