The present study evaluated, whether vaccination against both PCV2 and Lawsonia intracellularis in the same herd could be economically beneficial for the farmer and at the same time reduce the antibiotic consumption. The study was carried out in a wean-to-finish herd receiving 1000 weaned pigs ever 7th week. The herd experienced lowered average daily eight gain (ADWG), increased feed conversion rate (FCR), and high mortality in the finishers, and use of a group medication with antibiotics for treatment of clinical disease was frequently necessary.