A method to quantify infectious airborne pathogens at concentrations below the threshold of quantification by culture

dc.contributor.author Wang, Chong
dc.contributor.author Cutler, Timothy
dc.contributor.author Wang, Chong
dc.contributor.author Hoff, Steven
dc.contributor.author Zimmerman, Jeffrey
dc.contributor.author Hoff, Steven
dc.contributor.department Statistics
dc.contributor.department Veterinary Diagnostic and Production Animal Medicine
dc.contributor.department Agricultural and Biosystems Engineering
dc.date 2018-02-17T17:52:47.000
dc.date.accessioned 2020-07-07T05:13:36Z
dc.date.available 2020-07-07T05:13:36Z
dc.date.copyright Tue Jan 01 00:00:00 UTC 2013
dc.date.issued 2013-04-01
dc.description.abstract <p>In aerobiology, dose-response studies are used to estimate the risk of infection to a susceptible host presented by exposure to a specific dose of an airborne pathogen. In the research setting, host- and pathogen-specific factors that affect the dose-response continuum can be accounted for by experimental design, but the requirement to precisely determine the dose of infectious pathogen to which the host was exposed is often challenging. By definition, quantification of viable airborne pathogens is based on the culture of micro-organisms, but some airborne pathogens are transmissible at concentrations below the threshold of quantification by culture. In this paper we present an approach to the calculation of exposure dose at microbiologically unquantifiable levels using an application of the “continuous-stirred tank reactor (CSTR) model” and the validation of this approach using rhodamine B dye as a surrogate for aerosolized microbial pathogens in a dynamic aerosol toroid (DAT).</p>
dc.description.comments <p>This article is from <em>The Canadian Journal of Veterinary Research </em>77 (2013): 95. Posted with permission.</p>
dc.format.mimetype application/pdf
dc.identifier archive/lib.dr.iastate.edu/vdpam_pubs/70/
dc.identifier.articleid 1068
dc.identifier.contextkey 8720538
dc.identifier.s3bucket isulib-bepress-aws-west
dc.identifier.submissionpath vdpam_pubs/70
dc.identifier.uri https://dr.lib.iastate.edu/handle/20.500.12876/92099
dc.language.iso en
dc.source.bitstream archive/lib.dr.iastate.edu/vdpam_pubs/70/0-Canadian_Journal_of_Veterinary_Research_permission.pdf|||Sat Jan 15 01:40:21 UTC 2022
dc.source.bitstream archive/lib.dr.iastate.edu/vdpam_pubs/70/2013_Wang_MethodQuantify.pdf|||Sat Jan 15 01:40:23 UTC 2022
dc.subject.disciplines Large or Food Animal and Equine Medicine
dc.subject.disciplines Statistical Methodology
dc.subject.disciplines Veterinary Infectious Diseases
dc.subject.disciplines Veterinary Pathology and Pathobiology
dc.title A method to quantify infectious airborne pathogens at concentrations below the threshold of quantification by culture
dc.type article
dc.type.genre article
dspace.entity.type Publication
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