The effect of total and partial nephrectomy on the pharmacokinetics of intravenous paracetamol in humans

dc.contributor.author Karbownik, Agnieszka
dc.contributor.author Wolc, Anna
dc.contributor.author Polom, Wojciech
dc.contributor.author Porazka, Joanna
dc.contributor.author Szalek, Edyta
dc.contributor.author Grabowski, Tomasz
dc.contributor.author Wolc, Anna
dc.contributor.author Matuszewski, Marcin
dc.contributor.author Grzesowiak, Edmund
dc.contributor.department Animal Science
dc.date 2021-01-13T21:24:02.000
dc.date.accessioned 2021-02-24T21:13:05Z
dc.date.available 2021-02-24T21:13:05Z
dc.date.copyright Sun Jan 01 00:00:00 UTC 2017
dc.date.issued 2017-01-01
dc.description.abstract <p>Paracetamol is one of the most common analgesic and antipyretic drugs. Recently intravenous paracetamol has been widely used to treat moderate postoperative pain. Surgery is the main method of treatment of renal cancer. Total or partial nephrectomy can be performed, depending on the size and location of the tumor. Pharmacokinetics of drugs may depend on the type of surgery. The aim of the study was to compare the postinfusion pharmacokinetics of paracetamol in patients after total nephrectomy (TN) and nephron sparing surgery (NSS).The research was carried out on two groups of patients after nephrectomy: total (TN n = 37; mean [SD], age, 60.4 [10.9] years; BMI, 26.5 [3.8] kg/m2; creatinine clearance, Cl, 80.9 [37.1] mL/min) and nephron sparing surgery (NSS n = 17; 57.9 [16.5] years; BMI, 29.5 [5.3] kg/m2; Cl, 97.6 [27.8] mL/min). The patients were treated with paracetamol (PerfalganO Bristol-Myers Squibb) at an intravenous dose of 1.000 mg, which was infused for 15 minutes after surgery. The concentrations of paracetamol in the patients' plasma were determined by the HPLC method with UV detection (X = 261 run). The main pharmacokinetic parameters of paracetamol in the TN vs. NSS group were as follows: C.. 29.08 [17.39] vs. 27.54 [15.70] pg/mL (p = 0.6692); AUC5, 29.24 [13.86] vs. 34.85 [14.28] pg.h/mL (p = 0.2896); AUMC5,,,, 47.58 [26.08] vs. 62.02 [27.64] pg-h/mL (p = 0.1345); to. 2.34 [0.96] vs. 1.93 [0.50] h (p = 0.1415), respectively. In both groups the exposure to paracetamol was comparable. The t1/2 after nephron sparing surgery was shorter than after total nephrectomy. Therefore, these patients may demand more frequent drug administration. In the NSS group the C. of the analgesic was considerably reduced in men.</p>
dc.description.comments <p>This article is published as Karbownik A., Połom W., Porażka J., Szałek E., Grabowski T., Wolc A., Matuszewski M., Grześkowiak E. 2017. The effect of total and partial nephrectomy on the pharmacokinetics of intravenous paracetamol in humans. Acta Poloniae Pharmaceutica – Drug Research 74:929-935.</p>
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dc.identifier archive/lib.dr.iastate.edu/ans_pubs/659/
dc.identifier.articleid 1661
dc.identifier.contextkey 21061422
dc.identifier.s3bucket isulib-bepress-aws-west
dc.identifier.submissionpath ans_pubs/659
dc.identifier.uri https://dr.lib.iastate.edu/handle/20.500.12876/93414
dc.language.iso en
dc.source.bitstream archive/lib.dr.iastate.edu/ans_pubs/659/0-OA_Acta_Poloniae_Pharmaceutica___Drug_Research.pdf|||Sat Jan 15 01:24:51 UTC 2022
dc.source.bitstream archive/lib.dr.iastate.edu/ans_pubs/659/2017_Wolc_EffectTotal.pdf|||Sat Jan 15 01:24:52 UTC 2022
dc.subject.disciplines Animal Sciences
dc.subject.disciplines Medicinal Chemistry and Pharmaceutics
dc.subject.disciplines Research Methods in Life Sciences
dc.subject.disciplines Surgery
dc.subject.keywords paracetamol
dc.subject.keywords pharmacokinetics
dc.subject.keywords total nephrectomy
dc.subject.keywords nephron sparing surgery
dc.title The effect of total and partial nephrectomy on the pharmacokinetics of intravenous paracetamol in humans
dc.type article
dc.type.genre article
dspace.entity.type Publication
relation.isAuthorOfPublication 7103f024-4508-422f-82ff-1d5e544596a2
relation.isOrgUnitOfPublication 85ecce08-311a-441b-9c4d-ee2a3569506f
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