Entrepreneurship is the discovery and assessment of opportunities that leads to the creation of a new organization (Reynolds, 2005). Entrepreneurship in the U.S. continues to grow, but there is a limited number of studies specifically investigating fashion entrepreneurship. The purposes of this study are to investigate the college students' perceptions of fashion entrepreneurship in terms of perceived opportunities, perceived barriers/threats, and the intentions of entering fashion entrepreneurship, as well as to compare these viewpoints of the students from different geographic areas in the U.S. Comparisons were made between focus group interviews conducted at two different universities, one in the Southern region and the other one in the Appalachian region.