Serologic and fecal markers to predict response to induction therapy in dogs with idiopathic inflammatory bowel disease

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Otoni, Cristiane C.
Heilmann, Romy M.
García-Sancho, Mercedes
Sainz, Angel
Suchodolski, Jan S.
Steiner, Jörg M.
Jergens, Albert E.
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Ackermann, Mark
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Veterinary Pathology
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Background: Little information is available of markers that assess the disease course in dogs with idiopathic inflammatory bowel disease (IBD). Objectives: Evaluate relationship between disease severity and serum and fecal biomarkers in dogs with idiopathic IBD before and after treatment. Animals: Sixteen dogs with idioptahic IBD and 13 healthy dogs. Methods: Prospective case control study. Canine IBD activity index (CIBDAI) clinical score, serum concentrations of C-reactive protein (CRP), perinuclear antineutrophil cytoplasmic antibodies (pANCA), and serum and fecal canine calprotectin (cCP) were measured before and after 21 days of treatment. Results: Serum CRP (median 3.5 mg/L; range: 0.1-52.4 mg/L), fecal cCP (median 92.3 μg/g; range: 0.03-637.5 μg/g), and CIBDAI scores significantly increased in dogs with IBD before treatment compared with serum CRP (median 0.2 mg/L; range: 0.1-11.8 mg/L; P < .001), fecal cCP (median 0.67 μg/g; range: 0.03-27.9 μg/g; P < .001) and CIBDAI (P < .001) after treatment. No significant associations between CIBDAI scores and before or after treatment serum biomarkers. There was a significant association between fecal cCP and CIBDAI scores before treatment (rho = 0.60, P = .01). CRP and fecal cCP significantly decreased after treatment (median 3.5 mg/L v. 0.2 mg/L; P < .001 and 92.3 μg/g v. 0.67 μg/g; P = .001, respectively). Conclusions and Clinical Importance: Our data indicate that measurement of fecal cCP concentration is a useful biomarker for noninvasive evaluation of intestinal inflammation. Dogs with severe signs of GI disease more often have abnormal markers than dogs having less severe disease.
This is the published version of the following article: Otoni, Cristiane C., Romy M. Heilmann, Mercedes García‐Sancho, Angel Sainz, Mark R. Ackermann, Jan S. Suchodolski, Jörg M. Steiner, and Albert E. Jergens. "Serologic and fecal markers to predict response to induction therapy in dogs with idiopathic inflammatory bowel disease." Journal of Veterinary Internal Medicine 32, no. 3 (2018): 999-1008. DOI: 10.1111/jvim.15123. Copyright 2018 The Authors. Attribution 4.0 International (CC BY 4.0). Posted with permission.