Influenza A virus vaccine research conducted in swine from 1990 to May 2018: A scoping review

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2020-07-16
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Keay, Sheila
Poljak, Zvonimir
Klapwyk, Mackenzie
Friendship, Robert M.
O’Sullivan, Terri L.
Sargeant, Jan M.
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PLoS ONE
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O'Connor, Annette
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Veterinary Diagnostic and Production Animal Medicine
The mission of VDPAM is to educate current and future food animal veterinarians, population medicine scientists and stakeholders by increasing our understanding of issues that impact the health, productivity and well-being of food and fiber producing animals; developing innovative solutions for animal health and food safety; and providing the highest quality, most comprehensive clinical practice and diagnostic services. Our department is made up of highly trained specialists who span a wide range of veterinary disciplines and species interests. We have faculty of all ranks with expertise in diagnostics, medicine, surgery, pathology, microbiology, epidemiology, public health, and production medicine. Most have earned certification from specialty boards. Dozens of additional scientists and laboratory technicians support the research and service components of our department.
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Background: Influenza A viruses of swine (IAV-S) are a global zoonotic and economic concern. Primary control is through vaccination yet a formal evidence map summarizing vaccine research conducted in pigs is not available. Objective: Ten characteristics of English language primary IAV-S vaccine research, conducted at the level of the pig or higher, were charted to identify research gaps, topics for systematic review, and coverage across different publication types. Design: Six online databases and grey literature were searched, without geographic, population, or study type restrictions, and abstracts screened independently and in duplicate for relevant research published between 1990 and May 2018. Full text data was charted by a single reviewer. Results: Over 11,000 unique citations were screened, identifying 376 for charting, including 175 proceedings from 60 conferences, and 170 journal articles from 51 journals. Reported outcomes were heterogeneous with measures of immunity (86%, n = 323) and virus detection (65%, n = 246) reported far more than production metrics (9%, n = 32). Study of transmissibility under conditions of natural exposure (n = 7), use of mathematical modelling (n = 11), and autogenous vaccine research reported in journals (n = 7), was limited. Conclusions: Most research used challenge trials (n = 219) and may have poor field relevance or suitability for systematic review if the purpose is to inform clinical decisions. Literature on vaccinated breeding herds (n = 89) and weaned pigs (n = 136) is potentially sufficient for systematic review. Research under field conditions is limited, disproportionately reported in conference proceedings versus journal articles, and may be insufficient to support systematic review.
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This article is published as Keay, Sheila, Zvonimir Poljak, Mackenzie Klapwyk, Annette O’Connor, Robert M. Friendship, Terri L. O’Sullivan, and Jan M. Sargeant. "Influenza A virus vaccine research conducted in swine from 1990 to May 2018: A scoping review." PLoS ONE 15, no. 7 (2020): e0236062. DOI: 10.1371/journal.pone.0236062. Copyright 2020 Keay et al. Attribution 4.0 International (CC BY 4.0). Posted with permission.
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