Profile likelihood confidence intervals for ECx

dc.contributor.author Dixon, Philip
dc.contributor.author Goode, Katherine
dc.contributor.author Lay, C.
dc.contributor.department Statistics (LAS)
dc.date 2020-01-22T21:33:56.000
dc.date.accessioned 2020-07-02T06:58:13Z
dc.date.available 2020-07-02T06:58:13Z
dc.date.copyright Wed Jan 01 00:00:00 UTC 2020
dc.date.embargo 2020-01-22
dc.date.issued 2020-01-20
dc.description.abstract <p>Confidence intervals for effective concentrations (EC's) are commonly computed in dose response curve analyse. Profile intervals offer an alternative method for computing the confidence intervals in situations where delta method based confidence intervals produce intervals with values outside of a practical range. In this document, we describe the computation of profile intervals for EC's. We then introduce an R function, profile.ECx(), for computing these intervals from a dose response model fit by the drm() function in the drc package. Supplemental material includes three files of R code that define profile.ECx() and its helper functions and R code and data for the two examples.</p>
dc.description.comments <p>See the attached supplemental files below.</p>
dc.format.mimetype application/pdf
dc.identifier archive/lib.dr.iastate.edu/stat_las_reports/1/
dc.identifier.articleid 1000
dc.identifier.contextkey 16308774
dc.identifier.s3bucket isulib-bepress-aws-west
dc.identifier.submissionpath stat_las_reports/1
dc.identifier.uri https://dr.lib.iastate.edu/handle/20.500.12876/90703
dc.language.iso en
dc.source.bitstream archive/lib.dr.iastate.edu/stat_las_reports/1/0-ProfileCI.zip|||Fri Jan 14 17:57:17 UTC 2022
dc.source.bitstream archive/lib.dr.iastate.edu/stat_las_reports/1/ProfileCI.pdf|||Fri Jan 14 17:57:19 UTC 2022
dc.subject.disciplines Statistics and Probability
dc.supplemental.bitstream ProfileCI.zip
dc.title Profile likelihood confidence intervals for ECx
dc.type article
dc.type.genre report
dspace.entity.type Publication
relation.isAuthorOfPublication 7b3eb8d2-a569-4aba-87a1-5d9c2d99fade
relation.isOrgUnitOfPublication 264904d9-9e66-4169-8e11-034e537ddbca
File
Original bundle
Now showing 1 - 2 of 2
No Thumbnail Available
Name:
ProfileCI.pdf
Size:
212.01 KB
Format:
Adobe Portable Document Format
Description:
No Thumbnail Available
Name:
0-ProfileCI.zip
Size:
206.59 KB
Format:
Unknown data format
Description:
Collections