Disruption of female reproductive function by endotoxins

dc.contributor.author Bidne, K. L.
dc.contributor.author Dickson, M. J.
dc.contributor.author Keating, Aileen
dc.contributor.author Ross, J. W.
dc.contributor.author Baumgard, L. H.
dc.contributor.author Keating, A. F.
dc.contributor.department Animal Science
dc.date 2019-09-21T07:33:03.000
dc.date.accessioned 2020-06-29T23:41:10Z
dc.date.available 2020-06-29T23:41:10Z
dc.date.copyright Mon Jan 01 00:00:00 UTC 2018
dc.date.issued 2018-04-01
dc.description.abstract <p>Endotoxemia can be caused by obesity, environmental chemical exposure, abiotic stressors, and bacterial infection. Circumstances that deleteriously impact intestinal barrier integrity can induce endotoxemia and controlled experiments have identified negative impacts of lipopolysaccharide (LPS; an endotoxin mimetic) on folliculogenesis, puberty onset, estrus behavior, ovulation, meiotic competence, luteal function and ovarian steroidogenesis. In addition, neonatal LPS exposures have transgenerational female reproductive impacts, raising concern about early life contacts to this endogenous reproductive toxicant. Aims of this review are to identify physiological stressors causing endotoxemia, to highlight potential mechanism(s) by which LPS compromises female reproduction, and identify knowledge gaps regarding how acute and/or metabolic endotoxemia influence(s) female reproduction.</p>
dc.description.comments <p>Disclaimer: this is not the definitive version of record of this article. <em>This manuscript has been accepted for publication in Reproduction, but the version presented here has not yet been copy-edited, formatted or proofed. Consequently, Bioscientifica accepts no responsibility for any errors or omissions it may contain. The definitive version is now freely available at doi: <a href="https://doi.org/10.1530/REP-17-0406" target="_blank">10.1530/REP-17-0406</a> (2018).</em></p>
dc.format.mimetype application/pdf
dc.identifier archive/lib.dr.iastate.edu/ans_pubs/480/
dc.identifier.articleid 1475
dc.identifier.contextkey 14985361
dc.identifier.s3bucket isulib-bepress-aws-west
dc.identifier.submissionpath ans_pubs/480
dc.identifier.uri https://dr.lib.iastate.edu/handle/20.500.12876/9913
dc.language.iso en
dc.source.bitstream archive/lib.dr.iastate.edu/ans_pubs/480/2018_Keating_DisruptionFemaleManuscript.pdf|||Sat Jan 15 00:27:37 UTC 2022
dc.source.uri 10.1530/REP-17-0406
dc.subject.disciplines Agriculture
dc.subject.disciplines Animal Experimentation and Research
dc.subject.disciplines Animal Sciences
dc.subject.disciplines Cell and Developmental Biology
dc.title Disruption of female reproductive function by endotoxins
dc.type article
dc.type.genre article
dspace.entity.type Publication
relation.isAuthorOfPublication abe31007-187a-4174-864e-6871e3f9a0d7
relation.isOrgUnitOfPublication 85ecce08-311a-441b-9c4d-ee2a3569506f
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