Effects of in vivo dexamethasone administration on in vitro bovine polymorphonuclear leukocyte function

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1981-08-01
Authors
Roth, James
Kaeberle, Merlin
Roth, James
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Roth, James
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Veterinary Microbiology and Preventive Medicine
Abstract

Polymorphonuclear leukocyte function was evaluated in vitro after in vivo administration of a single dose of dexamethasone to cattle. Purified polymorphonuclear leukocytes from dexamethasone-treated cattle displayed enhanced random migration under agarose but impaired ingestion of Staphylococcus aureus, Nitro Blue Tetrazolium reduction, chemiluminescence, iodination, and antibody-dependent, cell-mediated cytotoxicity. The depression of iodination may have been related to a drop in the proportion of eosinophils present in the polymorphonuclear leukocyte preparations after dexamethasone administration.

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This article is published as Roth, J.A., and M.L. Kaeberle. 1981. Effects of in vivo dexamethasone administration on in vitro bovine polymorphonuclear leukocyte function. Infect Immun, 33:434-441. Posted with permission.

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