Decomposing the effects of physical activity and cardiorespiratory fitness on mortality

dc.contributor.author Wolfson, Julian
dc.contributor.author Stovitz, Steven
dc.contributor.author Lee, Duck-Chul
dc.contributor.author Blair, Steven
dc.contributor.author Sui, Xuemei
dc.contributor.author Lee, Duck-Chul
dc.contributor.author Shrier, Ian
dc.contributor.department Kinesiology
dc.date 2020-12-30T19:55:10.000
dc.date.accessioned 2021-02-26T02:28:47Z
dc.date.available 2021-02-26T02:28:47Z
dc.date.copyright Tue Jan 01 00:00:00 UTC 2019
dc.date.issued 2019-11-01
dc.description.abstract <p><h3 id="x-x-st0010">Background</h3> <p id="x-x-sp0025">Characterizing the effects of physical activity (PA) and cardiorespiratory fitness (CRF) on mortality is challenging because the causal relationship between PA, CRF, and other cardiovascular risk factors is unclear. <h3 id="x-x-st0015">Methods</h3> <p id="x-x-sp0030">To better understand the effects of PA and CRF on mortality, we re-analyzed data from 42,373 participants in the Aerobics Center Longitudinal Study (ACLS) using a modified version of VanderWeele's four-way causal effect decomposition method. The method was applied to decompose the causal effects of PA and CRF on median time to death into parts reflecting mediation, interaction, mediated interaction, and neither interaction nor mediation. <h3 id="x-x-st0020">Results</h3> <p id="x-x-sp0035">We found that 67% of the effect of PA on mortality was mediated by CRF, while the effect of CRF was not significantly mediated by PA. The effects of both PA and CRF were mediated to a small extent by hypertension and diabetes. There were no meaningful interactions. <h3 id="x-x-st0025">Conclusions</h3> <p id="x-x-sp0040">Our findings strengthen the evidence that the benefit on mortality from PA is largely mediated by its effect on CRF, and support efforts to increase longevity by encouraging PA</p>
dc.description.comments <p>This article is published as 103. Wolfson J, Stovitz SD, Blair SN, Sui X, Lee DC, Shrier I. Decomposing the effects of physical activity and cardiorespiratory fitness on mortality. <em>Global Epidemiology.</em> Nov 2019, Vol 1; 1000009. Doi: <a target="_blank">10.1016/j.gloepi.2019.100009.</a> </p>
dc.format.mimetype application/pdf
dc.identifier archive/lib.dr.iastate.edu/kin_pubs/75/
dc.identifier.articleid 1073
dc.identifier.contextkey 20878513
dc.identifier.s3bucket isulib-bepress-aws-west
dc.identifier.submissionpath kin_pubs/75
dc.identifier.uri https://dr.lib.iastate.edu/handle/20.500.12876/96543
dc.language.iso en
dc.source.bitstream archive/lib.dr.iastate.edu/kin_pubs/75/2020_LeeDC_Decomposing_the_effects_of_physical_activity.pdf|||Sat Jan 15 01:49:47 UTC 2022
dc.source.uri 10.1016/j.gloepi.2019.100009
dc.subject.disciplines Cardiology
dc.subject.disciplines Exercise Science
dc.subject.disciplines Kinesiology
dc.subject.disciplines Medical Humanities
dc.subject.disciplines Psychology of Movement
dc.subject.keywords Physical activity
dc.subject.keywords Cardiorespiratory fitness
dc.subject.keywords Diabetes
dc.subject.keywords Hypertension
dc.subject.keywords Mortality
dc.subject.keywords Mediation
dc.subject.keywords Interaction
dc.subject.keywords Causal effects
dc.title Decomposing the effects of physical activity and cardiorespiratory fitness on mortality
dc.type article
dc.type.genre article
dspace.entity.type Publication
relation.isAuthorOfPublication 4b9a255a-7593-4589-b7fa-5bdb5817d9d7
relation.isOrgUnitOfPublication f7b0f2ca-8e43-4084-8a10-75f62e5199dd
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