Plasmodium Oocysts: Overlooked Targets of Mosquito Immunity

Date
2016-01-01
Authors
Smith, Ryan
Barillas-Mury, Caroline
Smith, Ryan
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Altmetrics
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Smith, Ryan
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Research Projects
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Entomology
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Abstract

Although the ability of mosquitoes to limit Plasmodium infection is well documented, many questions remain as to how malaria parasites are recognized and killed by the mosquito host. Recent evidence suggests that anti-Plasmodium immunity is multimodal, with different immune mechanisms regulating ookinete and oocyst survival. However, most experiments determine the number of mature oocysts, without considering that different immune mechanisms may target different developmental stages of the parasite. Complement-like proteins have emerged as important determinants of early immunity targeting the ookinete stage, yet the mechanisms by which the mosquito late-phase immune response limits oocyst survival are less understood. Here, we describe the known components of the mosquito immune system that limit oocyst development, and provide insight into their possible mechanisms of action.

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<p>Published as Smith, Ryan C., and Carolina Barillas-Mury. "Plasmodium Oocysts: Overlooked Targets of Mosquito Immunity." Trends in parasitology 32, no. 12 (2016): 979-990. doi: <a href="https://doi.org/10.1016/j.pt.2016.08.012" target="_blank" title="Persistent link using digital object identifier">10.1016/j.pt.2016.08.012</a>. </p>
Keywords
mosquito, malaria, Plasmodium oocysts, innate immunity, hemocytes
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