Relationships between cardiorespiratory fitness, hippocampal volume, and episodic memory in a population at risk for Alzheimer’s disease

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dc.contributor.author Dougherty, Ryan
dc.contributor.author Schultz, Stephanie
dc.contributor.author Meyer, Jacob
dc.contributor.author Boots, Elizabeth
dc.contributor.author Ellingson, Laura
dc.contributor.author Meyer, Jacob
dc.contributor.author Van Riper, Stephanie
dc.contributor.author Stegner, Aaron
dc.contributor.author Edwards, Dorothy
dc.contributor.author Oh, Jennifer
dc.contributor.author Einerson, Jean
dc.contributor.author Korcarz, Claudia
dc.contributor.author Koscik, Rebecca
dc.contributor.author Dowling, Maritza
dc.contributor.author Gallagher, Catherine
dc.contributor.author Carlsson, Cynthia
dc.contributor.author Rowley, Howard
dc.contributor.author Bendlin, Barbara
dc.contributor.author Asthana, Sanjay
dc.contributor.author Hermann, Bruce
dc.contributor.author Sager, Mark
dc.contributor.author Stein, James
dc.contributor.author Johnson, Sterling
dc.contributor.author Okonkwo, Ozioma
dc.contributor.author Cook, Dane
dc.contributor.department Kinesiology
dc.date 2018-10-10T09:15:09.000
dc.date.accessioned 2020-06-30T05:45:36Z
dc.date.available 2020-06-30T05:45:36Z
dc.date.copyright Sun Jan 01 00:00:00 UTC 2017
dc.date.issued 2017-02-17
dc.description.abstract <p>Introduction: Cardiorespiratory fitness (CRF) has been shown to be related to brain health in older adults. In individuals at risk for developing Alzheimer's disease (AD), CRF may be a modifiable risk factor that could attenuate anticipated declines in brain volume and episodic memory. The objective of this study was to determine the association between CRF and both hippocampal volume and episodic memory in a cohort of cognitively healthy older adults with familial and/or genetic risk for Alzheimer's disease (AD).</p> <p>Methods: Eighty‐six enrollees from the Wisconsin Registry for Alzheimer's Prevention participated in this study. Participants performed a graded maximal exercise test, underwent a T‐1 anatomical magnetic resonance imaging scan, and completed the Rey Auditory Verbal Learning Test (RAVLT).</p> <p>Results: There were no significant relationships between CRF and HV or RAVLT memory scores for the entire sample. When the sample was explored on the basis of gender, CRF was significantly associated with hippocampal volume for women. For men, significant positive associations were observed between CRF and RAVLT memory scores.</p> <p>Summary: These results suggest that CRF may be protective against both hippocampal volume and episodic memory decline in older adults at risk for AD, but that the relationships may be gender specific.</p>
dc.description.comments <p>This article is published as 8. Dougherty R, Schultz S, Boots E, Ellingson L, Meyer J, Van Riper S, Stegner A Edwards D, Oh J, Einerson J, Korcarz C, Koscik R, Dowling M, Gallagher C, Carlsson C, Rowley H, Bendlin B, Asthana S, Hermann B, Sager M, Stein J, Johnson S, Okwonko O, Cook D. Relationships between cardiorespiratory fitness, hippocampal volume, and episodic memory in a population at risk for Alzheimer’s disease. <em>Brain and Behavior</em>; 2017, 7(3); e00625. DOI: <a href="https://doi.org/10.1002/brb3.625">10.1002/brb3.625</a>. </p>
dc.format.mimetype application/pdf
dc.identifier archive/lib.dr.iastate.edu/kin_pubs/36/
dc.identifier.articleid 1034
dc.identifier.contextkey 13051795
dc.identifier.s3bucket isulib-bepress-aws-west
dc.identifier.submissionpath kin_pubs/36
dc.identifier.uri https://dr.lib.iastate.edu/handle/20.500.12876/52518
dc.language.iso en
dc.source.bitstream archive/lib.dr.iastate.edu/kin_pubs/36/2016_MeyerJ_RelationshipsCardiorespiratoryFItness.pdf|||Fri Jan 14 23:47:06 UTC 2022
dc.source.uri 10.1002/brb3.625
dc.subject.disciplines Biomechanics
dc.subject.disciplines Cognitive Psychology
dc.subject.disciplines Exercise Science
dc.subject.disciplines Genealogy
dc.subject.disciplines Kinesiology
dc.subject.keywords APOE-e4
dc.subject.keywords exercise
dc.subject.keywords facognitionmily history
dc.subject.keywords physical activity
dc.title Relationships between cardiorespiratory fitness, hippocampal volume, and episodic memory in a population at risk for Alzheimer’s disease
dc.type article
dc.type.genre article
dspace.entity.type Publication
relation.isAuthorOfPublication 6d25a191-dd56-4965-a726-6dfe139e771a
relation.isOrgUnitOfPublication f7b0f2ca-8e43-4084-8a10-75f62e5199dd
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