Therapeutic potential of quercetin in cardiovascular and neuromuscular disorders
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2020-06
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Conditioning Medicine
Abstract
Chronic conditions including cardiovascular and neuromuscular disorders represent major causes of morbidity and mortality globally. Thus, effective therapeutic interventions are necessary to extend longevity and improve quality of life. One such intervention includes dietary enrichment with flavonol compounds. Flavonols are a large family of naturally occurring phytochemicals concentrated in many edible plants. One of the most abundant flavonols is quercetin, which includes its naturally occurring conjugates (i.e. isoquercetin, rutin). Quercetin has demonstrated antioxidant, anticarcinogenic, and anti-inflammatory properties and can activate molecular mediators of metabolic adaptation in skeletal and cardiac muscle. Because etiologies of cardiac and skeletal muscle disorders are often multi-faceted, a single therapeutic agent that targets multiple pathological processes is of great practical importance. Moreover, treatment efficacy is predicated on the notion that such an intervention be indefinitely sustainable and safe during chronic use while also remaining potent in aged individuals. In this review, we provide emergent evidence to suggest that supplemental use of quercetin may contribute to mitigation of a wide range of cardiovascular and neuromuscular conditions through various physiological mechanisms. In particular, the molecular underpinnings of therapeutic potential of quercetin in disease will be emphasized and potential implications for clinical therapy will be discussed.
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This article is published as Ballmann C, Quindry JC, Spaulding HR, and Selsby JT. Therapeutic Potential of Quercetin in Cardiovascular and Neuromuscular Disorders. Conditioning Medicine. 3:117-134, 2020.
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