Effect of type A Pasteurella multocida fractions on bovine polymorphonuclear leukocyte functions

Thumbnail Image
Date
1984
Authors
Ryu, Hyoik
Kaeberle, Merlin
Griffith, Ronald
Major Professor
Advisor
Committee Member
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract

The effect of various Pasteurella multocida fractions on bovine polymorphonuclear leukocyte (PMN) functions was examined in vitro by using two encapsulated strains, P-2383 and P-1062 (both are Carter capsular type A and of bovine origin). The ability of PMNs to ingest Staphylococcus aureus and iodinate protein was significantly inhibited in the presence of live cells, heat-killed whole cells, or saline-extracted capsules but not in the presence of the decapsulated heat-killed cells. None of the fractions of the two strains inhibited nitroblue tetrazolium reduction by PMNs. The saline extract did not inhibit the binding of iodine to protein by a reaction involving xanthine, xanthine oxidase, and horseradish peroxidase. The PMN inhibitory factor was further characterized as a heat-stable capsular material of greater than 300,000 molecular weight.

Series Number
Journal Issue
Is Version Of
Versions
Series
Academic or Administrative Unit
Type
article
Comments

This article is published as Ryu, Hyoik, Merlin L. Kaeberle, James A. Roth, and Ronald W. Griffith. "Effect of type A Pasteurella multocida fractions on bovine polymorphonuclear leukocyte functions." Infection and immunity 43, no. 1 (1984): 66-71. Posted with permission.

Rights Statement
Copyright
Sun Jan 01 00:00:00 UTC 1984
Funding
DOI
Supplemental Resources
Source
Collections